Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP), which incorporates community classifications of signaling pathway nodes (receptors, enzymes, transcription factors and co-nodes) and their cognate bioactive small molecules. We then mapped over 10,000 public transcriptomic or...
Fig. 1. An overview of Notch signaling pathway in SCLC, Notch signaling is conducted through Notch receptors and DSL family ligands. Canonically, the Notch receptor undergoes seven steps to activate the Notch signaling pathway: 1) Synthesis in ER; 2) S1 cleavage by a furine-like convertase in...
刘建勋中国中医科学院西苑医院 Professor Jianxun Liu:Chief researcher and doctoral supervisor of Chinese Academy of Chinese Medical Sciences (CACMS). Chief scientist of National Science and Technology Major (973) Project and Qihuang Project. Form...
Ingenuity pathway analysis (IPA) showed that CD8+ T cells in RT were characterized by downregulated OX40 and exhausted T cell signaling pathways, indicating that these cells are in a less activated but not exhausted state (Figure 5C). IPA also identified PDGF-BB as the top upstream factor ...
GBM aggressiveness (Fig.4A). In addition, the list contains several synaptic pathways such as glutamatergic and GABAergic signalling, suggesting that FMRP might regulate the connection of GBMs into neuronal networks, which is beneficial for tumor growth [59]. Since the WNT pathway might underlie ...
there was a truncating mutation in AXIN2 which is known to regulate β-catenin in the Wnt signaling pathway. The frequent mutations in SOX9 and ARID1A22were also present in the MC38 cell line. SOX9 is a transcription factor that inhibits Wnt signaling24and has a role in regulating cell dif...
Thus, this study initially employed two recombinant CHO cell lines with a 17.4-fold difference in specific productivity to study the differential expressions of genes related to the mTOR signaling pathway. High productivity has been associated partly with enhanced translation mechanisms [48]. We ...
were decreased in ARNTL2-silenced group;GGlycolysis rate of PANC-1 cells ARNTL2 knockdown was examined by a Seahorse XFe96 Glycolysis Stress Test analyzer;HWestern blot analysis identified that the protein levels of PI3K-Akt signaling pathway and glycolysis related molecules in PATU-8988 T cells ...
(cell budding, sporulation, conjugation with cellular fusion, endocytosis). A closer look at these genes allows us to observe the existence of a significant number related to the MAP kinase signaling pathway. The MAPK cascade is related to various cellular processes: the pheromone response pathway,...
We also find that CKI (KIN-19) plays a role not only in the Wnt/β-catenin pathway, but also in the Wnt spindle orientation pathway as well. Based on these findings, we establish a model for the coordination of cell-cell interactions and distinct Wnt signaling pathways that ensures the ...