-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout mice and on the antinociceptive effect exerted by σ1R antagonists on pain of different etiology, very consistently in neuropathic pain, but also in nociceptive, inflammatory, and visceral pain. ...
:The sigma 1 receptor (S1R) is a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes and has been shown to play important roles in various pathological disorders including pain and, as recently discovered, COVID-19. Employing structure- and QSAR-based drug design...
The sigma-1 receptor (σ1R), an endoplasmic reticulum chaperone protein, is widely distributed and regulates numerous intracellular processes in neurons. Nerve injury alters the structure and function of axotomized dorsal root ganglion (DRG) neurons, contributing to the development of pain. The σ1...
Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous recombination, and separate pharmacological studies in wild type (WT) mice were done to investigate the role of this receptor in the development of pain-related behaviours (thermal hyperalgesia and mechanical allodynia) in m...
The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal...
The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a genetically unrelated protein with a
Role of Sigma-1 Receptor/p38 MAPK Inhibition in Acupoint Catgut Embedding–Mediated Analgesic Effects in Complete Freund’s Adjuvant-Induced Inflammatory Pain 背景与目的 内质网伴侣蛋白Sigma-1受体(Sig-1R)和丝裂原活化蛋白激酶(MAPKs)参与疼痛的致病机制。穴位刺激在炎性疼痛中发挥抗痛觉过敏作用。然而,Sig-...
2022年5月25日,浙江大学医学院附属邵逸夫医院骨科赵凤东教授团队在EMBO Molecular Medicine在线发表了Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2的研究论文。该研究阐明了Sigmar1在破骨细胞分化中的作用机制,并发现其激动剂二甲啡烷在治疗骨质疏松等骨代谢相关疾病中的...
11. M. C. Ruiz-Cantero, R. González-Cano, M. Tejada, M. Santos-Caballero, G. Perazzoli, F. R. Nieto, E. J. Cobos, Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interacti...
Sigma-1 receptor antagonist 3 是 Sigma-1受体选择性拮抗剂,Ki 为 1.14 nM。它抑制 hERG,IC50为 1.54μM。它在神经性疼痛方面有研究的价值。 规格价格库存数量 1 mg¥ 828现货 5 mg¥ 1,990现货 10 mg¥ 3,230现货 25 mg¥ 5,290现货 ...