Recently, we reported that fluvoxamine (FLU), a potent sigma‐1 receptor (S1R) agonist, decreases the levels of key elements of fibrosis in the kidney and in lung. Therefore, here we investigated the antifibrotic effectiveness of FLU in mouse and human TM cells. Methods: Fibrosis was induced...
Sciences, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China Abstract (+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors...
Sigma-1 receptor (Sig-1R) is a chaperone protein in the ER that is involved in ER stress regulation, but little is known about its role in HD or the mechanisms for cell protection. Here we show that the Sig-1R agonist, PRE084 increases cell survival and counteracts the deleterious ...
Fluvoxamine is a potent sigma-1 receptor agonist that is suggested to have various effects on neuropsychiatric disorders. Fluvoxamine might be an effective treatment for TD with fewer side effects than tetrabenazine. 迟发性运动障碍(TD)的特征是无意识、反复的、无目的的运动,可影响身体的不同部位[1,2...
It has been suggested that sigma receptors are involved in anxiety since Lu 28-179, a sigma2-receptor agonist, has anxiolytic properties in rodents. In addition to the depressive animal model, phenytoin-sensitive sigma1-receptor agonists such as (+)-SKF-10,047 and dextromethorphan attenuate the...
Among SSRIs, fluvoxamine, a potent sigma-1 receptor agonist, has the highest affinity at sigma-1 receptors. Sigma-1 receptor agonists greatly potentiate nerve-growth factor (NGF)-induced neurite outgrowth in PC12 cells, an effect that is antagonized by treatment with the selective sigma-1 ...
52、muraT,IshimaT,IyoM,HashimotoK.Potentiationofnervegrowthfactor-inducedneuriteoutgrowthbyfluvoxamine:roleofsigma-1receptors,IP3receptorsandcellularsignalingpathways.PLoSONE2008;3:e255&MatsunoK,MitaS.SA4503:ANovelSigma1ReceptorAgonist.CNSDrugReviews1998;4:1-24.HashimotoK,ScheffelU,LondonED.Invivolabeli 53...
2) is a σ1R receptor agonist with an affinity of 860 nM (IC50) [222] developed for treating AD. Blarcamesine also has agonist activity at the muscarinic M1 receptor, and the NMDA receptor with affinities of 5 and 8 µM, respectively [222]. 2.2.1 Alzheimer’s Disease Pre-clinical ...
Among SSRIs, fluvoxamine, a potent sigma-1 receptor agonist, has the highest affinity at sigma-1 receptors. Sigma-1 receptor agonists greatly potentiate nerve-growth factor (NGF)-induced neurite outgrowth in PC12 cells, an effect that is antagonized by treatment with the selective sigma-1 ...
treatmentofTDisunclear.Recently,thesigma-1receptoragonistfluvoxamine wasreportedtobebeneficialforhyperkineticmovementdisorders.Method: Wereport5caseswithpostpsychoticdepressivedisorderofschizophreniaand TD.Allpatientsweregivenfluvoxamine100mg/d,andafterthesecondweek ...