No specific time period was chosen for article publication, although more emphasis was given to recent and up-to-date articles. 1.2 Overview of Neurological Disease and the Role of the Sigma Receptors 1.2.1 Alzheimer’s Disease Alzheimer’s disease (AD) is a neurogenerative disorder with a ...
While the precise biological functions of sigma receptors have not been elucidated, recent work has shed some light on to these enigmatic systems. Sigma receptors have recently been a target of drug development related to psychiatric and neurological disorders. Sigma ligands have also been shown to ...
Sigma-1 receptor (σ1R) has been identified as a chaperone protein, which modulate opioid receptors activities and the functioning of several ion channels, exerting a role in pain transmission. As such, it represents a druggable target to treat neuropathic pain. This study aims at investigating ...
Sigma-1 and sigma-2 receptors are endoplasmic reticular proteins capable of acting as chaperones to promote activity of various proteins that have been implicated in neuropsychiatric disorders [216]. Sigma-1 receptors modulate all major neurotransmitter systems and interact with inositol triphosphate (IP3...
Date Jan. 5, 1995The invention relates to methods for the treatment of central nervous system disorders, neurological disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma...
The σ1R is a ligand-operated chaperone protein at the mitochondrial-associated endoplasmic reticulum membrane (MAM), interacting with other proteins, ion channels, and receptors involved in signalling and cell survival mechanisms. The proteins that the σ1R interacts with are the inositol trisphosphat...
The signalling between the two organelles is primarily achieved by releasing calcium from inositol 1,4,5-trisphosphate receptors (IP3Rs) of the ER to mitochondria, where calcium is taken into via voltage dependent anion channel 1 (VDAC1) and mitochondrial calcium uniporter (MCU), which are ...
The sigma-1 receptor is a ligand-regulated molecular chaperone that modulates several receptors and ion channels1–3 and is involved in a variety of neurological disorders4–6. Consequently, in recent years this pharmacological target hdtS(h+eraeuls)er-gabcpspete,ieenσvunte1atirtzσche...
Hall AA, Herrera Y, Ajmo CT jr, Cuevas J, Pennypacker KR: Sigma receptors suppress multiple aspects of microglial activation. Glia. 2009, 57: 744-54. 10.1002/glia.20802. Article PubMed Google Scholar Zhang X-J, Liu L-L, Jiang S-X, Zhong Y-M, Yang X-L: Activation of the ζ re...
(E1R), a novel positive allosteric modulator of sigma-1 receptors.Experimental ApproachE1R was tested for sigma receptor binding activity in a [3H](+)-pentazocine assay, in bradykinin (BK)-induced intracellular Ca2+ concentration ([Ca2+]i) assays and in an electrically stimulated rat vas ...