Sickle Cell Disease (Clinical) Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous...
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Haemoglobin molecules that include mutant ...
AIM. To estimate the prevalence, incidence, and characteristics of Unruptured Intracranial Aneurysms (UIAs) in (sickle cell disease) SCD patients and compare same with the metrics and features in the general population. METHOD. The Data repositories, Medline (PubMed), Embase and Web of science ...
Gaston4, Kwaku Ohene‑Frempong5, Lakshmanan Krishnamurti6, Wally R. Smith7, Julie A. Panepinto8, David J. Weatherall9, Fernando F. Costa10 and Elliott P. Vichinsky11 Abstract | Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB...
Sickle cell disease (SCD) does not occur in the indigenous German population. However, with the increasing numbers of immigrants its prevalence is steadily rising. Nevertheless, robust epidemiological data is not available for Germany and, consequently, the German newborn screening (NBS) program does...
Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the Emergency Department and hospitalization in patients with sickle cell disease (SCD). Although two new agents have been approved by the Food and Drug Administration f
| 906 | haematologica/the hematology journal | 2007; 92(07) Clinical outcomes in children with sickle cell disease Children were considered lost to follow-up if not seen for more than 2 years. For children who had not been seen for more than 1 year, information was obtained by contacting ...
The purpose of this paper was to review the research examining the epidemiology of and costs associated with sickle cell anaemia (SCA). Although there is general acceptance that Black populations are at greatest risk of the disease, estimates of disease incidence and prevalence vary greatly among ...
B, Association of sickle cell trait with incidence of any coronary heart disease (CHD). The follow-up periods were 1993 and 1998 to 2014 for the Women’s Health Initiative (WHI) study, 2003 to 2014 for the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, 2002 to ...
Prevalence In some parts of Africa, 45% of the population is heterozygous for the βS gene, in the USA and Caribbean about 8% carry one βS gene. Incidence of homozygous sickle cell disease in the USA is 1 in 625 births. Prevalence is lower in the Mediterranean basin, Saudi Arabia, an...