Its impact is particularly pronounced in regions where malaria is common, as the sickle cell trait provides some resistance to malaria, thereby contributing to higher rates of SCD prevalence.The mutation of the HBB gene on chromosome 11 causes the SCD which encodes the beta-globin su...
A century after discovery of sickle cell disease: keeping hope alive! The author discusses the increased prevalence of sickle cell disease around the world. Topics covered include estimation of the global burden brought by th... D Mohanty - 《Indian Journal of Medical Research》 被引量: 3发表...
In December 2023, the FDA approved two groundbreaking gene therapies for sickle cell disease (SCD) – Casgevy and Lyfgenia, tailored for pediatric patients aged 12 years and older. These drugs offer a curative approach by addressing the genetic ...
BackgroundThe global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income cou... FB Piel,SI Hay,S Gupta,... - 《Plos Medicine》 被引量: 336发表: 2013年 A global perspective on sickle cell disease. The glo...
It is estimated that 75–85% of children born with SCD are born in Africa, where mortality rates for those under age 5 range from 50% to 80% (Aygun and Odame, 2012 and Makani et al., 2011). The highest prevalence of sickle-cell trait (SCT) in Africa occurs between the ...
Healthy life expectancy: the number of years that a person at a given age can expect to live in good health, taking into account mortality and disability. Years lived with disability: computed as the prevalence of different disease sequelae and injury sequelae multiplied by disability weights for...
BackgroundThe global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income cou... FB Piel,SI Hay,S Gupta,... - 《Plos Medicine》 被引量: 336发表: 2013年 A global perspective on sickle cell disease. The glo...
Pediatric Hematology & Oncology focuses on the diagnosis and treatment of blood disorders and cancers in children. This specialized field addresses conditions such as leukemia, lymphoma, sickle cell disease, and hemophilia. Treatment modalities include chemotherapy, radiation therapy, bone marrow transplantat...
The collected data indicate that the distribution of gout is uneven across the globe, with prevalence being highest in Pacific countries. Developed countries tend to have a higher burden of gout than developing countries, and seem to have increasing prevalence and incidence of the disease. Some ...
The estimates are also informed by covariates that help predict haemoglobin concentrations, including maternal education,15 proportion of population in urban areas, mean latitude, prevalence of sickle-cell disorders and thalassaemias,16 mean body-mass index (BMI)17 for women, and mean weight-for-age...