Sickle cell disease is caused by a genetic mutation in the hemoglobin within red blood cells. This abnormal hemoglobin sticks together, changing the shape of a person's red blood cells. These misshapen cells can disrupt blood flow, leading to pain, anemia, infection, and other complications. Pe...
TREATMENT AND PREVENTION OF SICKLE-CELL CRISISdoi:10.1016/S0140-6736(72)90766-0RobertM. NalbandianThe Lancet
Sickle cell disease is an inherited disorder of haemoglobin synthesis. Get better at looking after the children in front of you by reading this post.
Sickle cell crisis, a hallmark of sickle cell anemia, arises from the unique pathophysiology of this inherited hemoglobinopathy. The condition, characterized by a point mutation in the beta chain of the globin gene, leads to the synthesis of abnormal HbS protein, causing various crises. Vaso-occlu...
Sickle Cell Disease Sickle cell disease complications during pregnancy include sickle cell crisis affecting the bones and joints which can occur at any time during pregnancy, labour and the puerperium. Crises during the last 4 weeks of pregnancy and the first 4 days after delivery are more severe...
A pain crisis can be promoted by preceding dehydration, infection, injury, cold exposure, emotional stress, or strenuous exercise. As a prevention measure, persons with sickle cell anemia should avoid extremes of heat and cold. Pain crises require analgesia for pain and increased fluid intake. Deh...
Prevention of Morbidity in SCA pilot trial POMS2b: Prevention of Morbidity in SCA Phase 2 trial PPI: participants and public involvement QOL: quality of life RCT: randomised controlled trial RfPB: Research for Participant Benefit SCA: sickle cell anaemia SpO2: oxygen saturation WISC-...
Interventions for treating painful sickle cell crisis during pregnancy Background: Sickle cell disease is a group of genetic haemoglobin disorders. All over the world, about 300,000 children with these disorders are born each ... AJ Martí-Carvajal,Guiomar E Pea-Martí,G Comunián-Carrasco,.....
Acute splenic sequestration crisis in a 70-year-old patient with hemoglobin SC disease. J Investig Med High Impact Case Rep 2016;4:2324709616638363. 34. Adams R, McKie V, Nichols F, et al. The use of transcranial ultrasonogra- phy to predict stroke in sickle cell disease. N ...
What can I do to prevent a sickle cell crisis?A sickle cell crisis may be caused by illness, changes in temperature, stress, dehydration, or being at high altitudes. Do the following to help prevent a sickle cell crisis:Drink liquids as directed. Dehydration can increase your risk for a ...