New Drug To Treat Sickle Cell Crisis Begins Pilot Study In PatientsGlycoMimetics, Inc
The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A 2A adenosine receptor agonist. Optionally, the meth... JM Linden,K Wallace,RA Figler,... - US 被引量: 28发...
(Table 1). Associated comorbidities include history and frequency of ACS and painful crisis, coexisting asthma, presence of PH andVTEand/orarterial thromboembolism, as well as SDB. Finally, the nonspecific termsickle cellchronic lung diseasehas been used to describe patients with lung disease ...
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BM was harvested from these patients outside of a sickle cell vaso-occlusive crisis. The remaining one hundred and seventy patients had osteonecrosis not related to SCD (called “ON patients”) and consisted of 85 female and 85 male patients (Age range of patients: 14–40 years; Average age...
88,90 In chronic myeloid leukemia stem cells, similarly, the chronic phase is at the HSC level, but the myeloid blast crisis leukemia stem cells are at the stage of GMP.91 Clarke et al were the first to prospectively isolate or enrich human breast cancer stem cells,92 and their studies ...
The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., ...
A specific dosage regimen of buprenorphine achieves pain relief from painful episodes due to sickle cell disease. The dosage regimen comprises administering to a patient in need of pain relief from sickle cell disease at least one BTDS transdermal patch. Alternatively, the dosing regimen comprises ...
Sickle cell crisis is a very severe painful condition resulting in tissue infarction of different organs (brain, liver heart, bone, spleen) caused by the precipitation of sick-led cells in patients with high level of haemoglobin S (HbS). Red cell exchange (RCE) is a safe and rapid ...
The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A 2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., ...