Sickle Cell Anemia; Findings in Sickle Cell Anemia Reported from A.A. Abusham and Co-ResearchersAhmed Abusham
The hematological and clinical data in 97 sickle-cell anemia cases and hematological findings of their parents are reported. In spite of the low Hb values of the patients, they tolerated their anemia and very rarely required blood transfusions. The Hb F levels of the patients were in general ...
Hemoglobin studies have been presented on a patient with clinically typical sickle cell anemia who was found to possess two major adult hemoglobins, Hb S and hybrid Hb GPhil./S. Four hemoglobins were demonstrated in his mother, Hb A, GPhil.,S and GPhil./S, in somewhat unexpected and as...
Sickle cell anemia disease (SCAD) is a molecular disease1that occurs due to the gene mutation2. The low oxygen affinity of a mutant hemoglobin is a characteristic of SCAD3,4. It has already been confirmed2that one of the glutamic acid residues of Pro–Glu–Glu (PGG) present in normal he...
Cardiovascular findings are described in seven children with sickle cell anemia. Clinically the following features were noted: (1) exertional dyspnea and fatigue; (2) wide fixed splitting of the second heart sound; (3) third "filling" heart sound in five of the seven cases; (4) systolic mur...
Ocular findings in homozygous sickle cell anemia in Jamaica###The progression of sickle cell eye disease in Jamaica###Unusual chorioretinal degeneration in sickle cell disease. Possible sequelae of posterior ciliary vessel occlusion###A randomized clinical trial of feeder vessel photocoagulation of proli...
Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice 2015, Blood Cells, Molecules, and Diseases Show abstract Comparative analysis of pain behaviours in humanized mouse models of sickle cell anemia 2016, PLoS ONE Show abstractView all citing articles on Scop...
13 We did not have genotype information and did not categorize life expectancy for sickle cell anemia or other hemoglobinopathies. The projected life expectancy for SCD based on current mortality rates (54 years) is higher in our study than values reported from studies based on mortality ...
Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous condition, is the only 1 of...
Sickle Cell Anemia Sickle cell is a homogenous genetic anemia caused when an abnormal gene (hemoglobin S or HbS) causes the substitution of the amino acid valine, for another, glutamic acid (Amundsen et al., 1984). The sickle gene protects heterogeneous carriers (HbC) from P. falciparum in ...