This study presents a biomacromolecular hydrogel delivery system with apoferritin nanoparticles for effective delivery of small interfering high mobility group protein (siHMGB1). The system was designed to promote the polarization of M1 macrophages to the M2 phenotype by downregulating the HMGB1/TLR4/NF-...
Non-small cell lung cancer (NSCLC)High-mobility group box 1 (HMGB1)NF-kappa BMicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The dysregulation of miR-449a is found in many types of malignancies and is associat...
Furthermore, GA obviously inhibited APAP-induced HMGB1-TLR4 signal activation, as evaluated by reduced hepatic HMGB1 release, p-IRAK1, p-MAPK and p-I魏B expression as well as the productions of TNF-伪 and IL-1尾. In addition, GA attenuated hepatic neutrophils recruitment and macrophages ...