我们发现 SHP-1 蛋白在 SMMC-7721 和 MHCC97H 细胞中的表达明显下调。白杨素显著抑制 SMMC-7721 和 MHCC97H 细胞球形成,上调 SHP-1 蛋白的表达,并降低 SMMC-7721 细胞中 p-STAT3 和 Twist1 的表达。此外,敲除 SMMC-7721 细胞中 SHP...
Alteration of SHP-1/p-STAT3 signaling: a potential target for anticancer therapy. Int J Mol Sci. 2017;18, pii: E1234.Huang TT, Su JC, Liu CY, Shiau CW and Chen KF: Alteration of SHP‑1/p‑STAT3 signaling: A po...
经SHP-1激动剂处理后,小鼠肺泡灌洗液中巨噬细胞和外周血单核细胞的百分率也显著降低,提示SHP-1激动剂可能通过靶向巨噬细胞和重塑免疫纤维生态位来减轻肺纤维化。 在人单核细胞来源的巨噬细胞中,SHP-1激动剂治疗下调了CSF1R的表达,并使STAT3/NFκB信号失活,最终抑制了巨噬细胞的存活和扰乱了巨噬细胞的极化。依赖...
采用甲基化特异性聚合酶链反应方法检测SHP-1基因的甲基化水平,通过Western印迹检测p-STAT3水平。结果 在高危组SHP-1启动子的甲基化阳性患者为64.44%(29/45),明显高于低危组22.92%(11/48),SHP-1启动子的甲基化状态在高危组患者广泛存在;高危组p-STAT3阳性患者为66.67%(30/45),而在低危组p-STAT3阳性患者仅...
The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1), a non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of phosphorylated signal transducer and activator of transcription 3 (STAT3) and linked to tumor development. In this present ...
也有研究提示, SHP2可以对STAT3的活性进行负向调节 来自 《世界华人消化杂志》官网 喜欢 0 阅读量: 850 作者: 王建强,黄缘 展开 摘要: Primary liver cancer is a kind of malignant tumor that occurs in liver cells and bile duct epithelial cells. There is a great difference in the incidence...
LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway Li Xie Chiqi Chen Junke Zheng Cell Death & Disease(2024) Associated content Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1 Nature Cell BiologyResearch Briefing23 Feb 2024 ...
SHP-1是JAK/STAT信号通路主要的负向调节因子之一,研究表明SHP-1活性增加导致STAT3去磷酸化,并增加肝癌细胞对肿瘤坏死因子相关性凋亡诱导配体(TRAIL)的敏感性,从而诱导肝癌细胞凋亡,达到抗肿瘤作用。索拉非尼作为第一个也是目前仅有的一个被批准用于肝癌治疗的靶向药物,是多种激酶抑制剂,可以抑制Raf-1和其他酪氨酸...
STAT1 (E23), STAT2 (C-20), STAT3 (C-20), extracellular signal-regulated kinase-1/2 (K-23), JAK1 (H-106), TYK2 (C-20), SHP-1 (G-20), and SHP-2 (C-18) pAbs were from Santa Cruz Biotechnology (Santa Cruz, CA). The rabbit anti-human SOCS3 monoclonal antibody was from ...
SHP-1 reverses trastuzumab resistance and migration in HER2-positive breast cancer cells through the stat3/p-stat3 pathway Decreased expression of Src homology region 2 domain containing protein tyrosine phosphatase 1 (SHP-1) was found in human breast cancer cell lines and primary breast cancers. As...