也有研究提示, SHP2可以对STAT3的活性进行负向调节 来自 《世界华人消化杂志》官网 喜欢 0 阅读量: 850 作者: 王建强,黄缘 展开 摘要: Primary liver cancer is a kind of malignant tumor that occurs in liver cells and bile duct epithelial cells. There is a great difference in the incidence...
(SH2)-containing phosphatase (SHP1), cytokine-inducible (CIS) SH2-containing protein, suppressor of cytokine signaling-1 (SOCS1) and protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) in six HTLV-1 negative and seven HTLV-1 positive T-cell ...
结果 1.B淋巴瘤细胞株中STAT家族及其负向调节因子的表达 (1)以IM9细胞为对照组,结果显示:KM3细胞中STAT1,STAT2, STAT5mRNA表达水平较IM9细胞高,STAT3,STAT4,STAT6mRNA表达水平较IM9细胞低;L428细胞STAT1,STAT2,STAT3,STAT4,STAT5mRNA表达水平较IM9细胞高,STAT6mRNA表达水平较IM9细胞低;L428-CD99细胞...
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma. Blood. 2006;108(8):2796-2803.Y. Han, H. M. Amin, B. Franko, C. Frantz, X. Shi, and R. Lai, "Loss of SHP1 enhances JAK3...
2012. Inhibition of STAT3 sig- naling and induction of SHP1 mediate antiangiogenic and anti- tumor activities of ergosterol peroxide in U266 multiple myeloma cells. BMC Cancer 12: 28.Rhee YH, Jeong SJ, Lee HJ, etal. Inhibition of STAT3 sig- naling and induction of SHP1 mediate anti...
Restoration of shp1 expression by 5-AZA-2′-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma. Y Han,H M Amin,C Frantz,B Franko,J Lee,Q Lin,R Lai. Leukemia . 2006
This resulted in a corresponding down-regulation of activated STAT3 in a similar time dependent manner. Treatment of Ly3 and DHL2 cells with 5-Aza for 0-6 days significantly (p=0.0008 for Ly3 and p=0.03 for DHL2) reduced the cell survival (40% decrease at day 6). To further ...
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK+ ALCL) is characterized by constitutive activation of the Janus kinase (JAK)3/signal transducers and activators of transcription 3 (STAT3) signaling pathway. SHP1, a tyrosine phosphatase that negatively regulates JAK/STAT, ...
Zn inhibits STAT3 phosphorylation through up-regulation of SHP1 activity.Liu, MingJieBao, ShengyingR. Napolitano, JessicaL. Burris, DaraYu, LianboTridandapani, SusheelaL. Knoell, Daren