An opioid is any compound, regardless of the structure, which has the functional and pharmacological properties of an opiate. Endogenous opioids are natural ligands for opioid receptors found in animals. Synthetic compounds include hydrocodone; oxycodone; hydromorphone; heroin; antagonists such as ...
Many cancer patients experience chronic and breakthrough pain necessitating the use of both immediate release (IR) and extended release (ER) opioids. The common strategy in treating chronic cancer pain is using ER opioids with the addition of IR opioids for breakthrough pain. The National Comprehen...
The short-acting drugs can complement methadone and buprenorphine to help patients get faster relief and help patients stay in the hospital to help with long-term management, say authors.
A phase I clinical trial The drug investigated in these studies, Opra Kappa, also with another long-acting KOP-r antagonist, JDTic, was referred to as LY2456302 [(S)-3-fluoro-4-(4-((2 (3,5-di- suspended after 2 of the 6 subjects who received this methylphenyl)pyrrolidin-1-yl)...
Brain damage and death were associated with epidural steroid injection only when opioids or local anesthetics were... DR Fitzgibbon,KL Posner,KB Domino,... - 《Anesthesiology》 被引量: 315发表: 2004年 Clinical pharmacokinetics of local-anesthetics The introduction of the new long acting local ...
Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short ...
Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously atten...
but where methadone or buprenorphine provide inadequate relief, may benefit hospitalized patients suffering from opioid withdrawal symptoms. While current U.S. guidelines do not recommend short-acting opioids for these patients, an expert commentary from the University of Toronto and Harvard Medical School...
Short-Acting and Long-Acting Opioids Utilization among Women Diagnosed with Endometriosis in the United States: A Population-based Claims StudyEndometriosisOpioidsPainObjective To determine the prevalence and pattern of opioid use in endometriosis and the characteristics of patients prescribed an opioid ...
Long-acting opioids and short-acting opioids: appropriate use in chronic pain management. Pain Med 2009; 10 Suppl 2:S79-S88.Fine PG, Mahajan G, McPherson ML. Long-acting opioids and short-acting opioids: appropriate use in chronic pain management. Pain Med 2009; 10(Suppl 2): S79-88....