An opioid is any compound, regardless of the structure, which has the functional and pharmacological properties of an opiate. Endogenous opioids are natural ligands for opioid receptors found in animals. Synthetic compounds include hydrocodone; oxycodone; hydromorphone; heroin; antagonists such as ...
Long- and short-acting opioids in cancer pain management: What is the best ratio? 喜欢 0 阅读量: 34 作者:A Wiesenthal,N Moryl,PA Glare 摘要: Many cancer patients experience chronic and breakthrough pain necessitating the use of both immediate release (IR) and extended release (ER) opioids....
A phase I clinical trial The drug investigated in these studies, Opra Kappa, also with another long-acting KOP-r antagonist, JDTic, was referred to as LY2456302 [(S)-3-fluoro-4-(4-((2 (3,5-di- suspended after 2 of the 6 subjects who received this methylphenyl)pyrrolidin-1-yl)...
However their long-term use is limited because of the development of tolerance and dependence. Due to its importance in therapy, different strategies hav... I Gomes,A Gupta,J Filipovska,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 429...
Main result Compared with short-acting opioids, use of long-acting opioids was associated with increased risk for unintentional overdose overall, with the risk seeming to be highest in the first 14 days (Table). Conclusion In veterans with chronic noncancer pain, use of long-acting opioids was...
Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain: Protocol for a network meta-analysis of randomized controlled trialsKeyword Highlighting Highlight selected keywords in the article text.Clinical trialists may explore competing interventions , not to demonstrate the ...
Long-acting opioids and short- acting opioids: appropriate use in chronic pain management. Pain Med. 2009;10(Suppl 2):S79-S88.Fine PG, Mahajan G, McPherson ML. Long-acting opioids and short- acting opioids: appropriate use in chronic pain management. Pain Med. 2009;10(suppl 2):S79-S88...
Daily use of longacting opioids vs. daily use of shortacting opioids increases the risk of hypogonadism in men, one of the first studies to evaluate this association, presented during the 2012 American Academy of Pain Medicine Annual Meeting, has found.MPR First Report...
"Long- or Short-Acting Opioids for Chronic Non-Malignant Pain? A Qualitative Systematic Review." Acta Anaesthesiologica Scandinavica 58, no. 4 (April 2014): 390-401. doi:10.1111/aas.12279.Pedersen L, Borchgrevink PC, Riphagen II, Fredheim OM. Long- or short-acting opioids for chronic non...
In light of the recently released US Centers for Disease Control and Prevention guidelines on opioid use in chronic noncancer pain, there is a pressing need to better characterize the effectiveness of long- and short-acting opioids.Ghodke, AmeerBarquero, StephanieChelminski, Paul R.Ives, Timothy...