目的基于sGC-cGMP-PKG信号通路研究桂郁金(Curcuma kwangsiensis root tubers,GYJ)水提物对异丙肾上腺素(isoproterenol,ISO)诱导小鼠心肌肥厚的改善作用及相关机制.方法将72只KM雄性小鼠随机分为正常对照组,模型组,普萘洛尔(40 mg/kg)组以及GYJS低(1 g/kg),中(2 g/kg),高(4 g/kg)剂量组.除正...
sGC-cGMP-PKG pathway in diabetes condition was altered by empagliflozin To further explore the potential molecular mechanism regarding protective action of empagliflozin in vivo, the activity of sGC-cGMP-PKG pathway were examined. According to Western blot analysis or immunohistochemistry results, p-eNOS...
To the editor: Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets? LS Chen,Redkar,JE Cortes,... 被引量: 0发表: 0年 Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway Bacterial LPS...
Asger A, Jonas AP, Jacob J,et al.sGC - cGMP - PKG pathwaystimulation protects the healthy but not the failing right ventricle ofrats against ischemia and reperfusion injury[J]. International Jour-nal of Cardiology,2016,223 (15) :674 -680....
Sun J, Aponte AM, Kohr MJ, Tong G, Steenbergen C, Murphy E: Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sgc/cgmp/pkg signaling? Free Radic Biol Med 2013;54:105-112.Sun J, Aponte AM, Kohr MJ, Tong G, Steenbergen C, Murphy E. ...
Mechanistically, SO_2 upregulated the protein levels of sGC and PKG dimers, while HDX inhibited it, indicating SO_2 could promote cGMP synthesis through sGC activation. Furthermore, the dimerization of sGC and PKG and vasodilation induced by SO_2 in precontracted rings were significantly prevented...
Retracted: Helicid Reverses the Effect of Overexpressing NCALD , Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Modeldoi:10.1155/2023/9841212Journal of Healthcare EngineeringJournal of Healthcare Engineering
Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza , Mediates sGC/cGMP/PKG Translocation in Experimental Vasospasm[J] . Chih-Zen Chang,Shu-Chuan Wu,Aij-Lie Kwan,John H. Zhang.BioMed Research International . 2014C.-Z. Chang, S.-C. Wu, and A.-L. Kwan, "Magnesium lithos...
Soluble guanylyl cyclase (sGC); protein kinase cGMP-dependent type 1 (PRKG1; PKG1)Mouse studies suggest activating the sGC and PKG1 pathway could help treat neuropsychiatric disorders such as ADHD. Further details on the research, next steps and licensing status are discussed in the article.Sci...
Altogether, activation of the NLRP3 inflammasome by iNOS in CS-exposed HAECs may be mediated by the sGC/cGMP/PKG/TACE/TNF- α pathway.#These results link iNOS to NLRP3 in CSE-stimulated HAECs through the sGC/cGMP/PKG/TACE/TNF-α pathway. The findings identify a mechanism through which ...