The fusion gene was detected by 5'-rapid amplification of cDNA ends (5'RACE). The tumor was found to be in an advanced stage with multiple lymph node metastases. The histological characteristics of the tumor were different from those of XP11tRCC with other more frequently detected fusion ...
Fusion-expressing tubuloids adopt a tRCC-like phenotype and gene expression signature in vitro and grow as clear cell RCC upon xenotransplantation in mice. Genome-wide binding analysis suggests that SFPQ-TFE3 reprograms gene expression signatures by widespread, aberrant DNA binding. Combining these ...
PSF/SFPQ Is a very common gene fusion partner in TFE3 rearrangement–associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers. Am J Surg Pathol 39: 1181–1196, 2015.PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated ...
Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neu- roblastoma. Am J Surg Pathol 2009;33:1416-20.Mio T,Keisuke K,Kiyoshi G,et al.Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.[J]...
We developed and characterized a mouse model and inducible cell line expressing the SFPQ-TFE3 gene fusion to aid in biomarker and therapy development for this tumor type. We generated a murine knock-in model at the Rosa26 locus expressing the human SFPQ (exons 1-9) -TFE3 (exons 5-10) ...
PSF/SFPQ Is a very common gene fusion partner in TFE3 rearrangement–associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers. Am J Surg Pathol 39: 1181–1196, 2015.PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated ...