In this case report, we presented a case of Xp11tRCC with the SFPQ/PSF-TFE3 chimeric gene. The fusion gene was detected by 5'-rapid amplification of cDNA ends (5'RACE). The tumor was found to be in an advanced stage with multiple lymph node metastases. The histological characteristics ...
Fusion-expressing tubuloids adopt a tRCC-like phenotype and gene expression signature in vitro and grow as clear cell RCC upon xenotransplantation in mice. Genome-wide binding analysis suggests that SFPQ-TFE3 reprograms gene expression signatures by widespread, aberrant DNA binding. Combining these ...
PSF/SFPQ Is a very common gene fusion partner in TFE3 rearrangement–associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers. Am J Surg Pathol 39: 1181–1196, 2015.PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated ...
Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neu- roblastoma. Am J Surg Pathol 2009;33:1416-20.Mio T,Keisuke K,Kiyoshi G,et al.Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.[J]...
Translocation Renal Cell Carcinomas (tRCC) are characterized by gene fusions that drive expression of chimeric TFE3 (Xp11.2) or TFEB (6p21.2). We developed and characterized a mouse model and inducible cell line expressing the SFPQ-TFE3 gene fusion to aid in biomarker and therapy development ...
PSF/SFPQ Is a very common gene fusion partner in TFE3 rearrangement–associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers. Am J Surg Pathol 39: 1181–1196, 2015.PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated ...