SFPQ-TFE3促使肾类器官癌变:研究人员将 SFPQ-TFE3导入两种独立的人体肾小管类器官模型 wk16 和 wk17 中。结果发现,与对照组相比,表达 SFPQ-TFE3的类器官在体外呈现出 tRCC 样的表型,细胞形态发生明显改变,出现多层、实性结构且细胞具有清晰的细胞质,类似透明细胞肾细胞癌(ccRCC)。将这些类器官原位移植到免疫缺...
Translocation Renal Cell Carcinomas (tRCC) are characterized by gene fusions that drive expression of chimeric TFE3 (Xp11.2) or TFEB (6p21.2). We developed and characterized a mouse model and inducible cell line expressing the SFPQ-TFE3 gene fusion to aid in biomarker and therapy development ...
In this case report, we presented a case of Xp11tRCC with the SFPQ/PSF-TFE3 chimeric gene. The fusion gene was detected by 5'-rapid amplification of cDNA ends (5'RACE). The tumor was found to be in an advanced stage with multiple lymph node metastases. The histological characteristics ...
Xp112 translocation renal cell carcinoma with SFPQ/PSF-TFE3 fusion gene: A case report with unusual histopathologic findings Ishikawa, Noriyoshi,Nagase,etc.Xp11.2 translocation renal cell carcinoma with SFPQ/PSF-TFE3 fusion gene: A case report with unusual histopathologic findings[... N Ishikawa,M...
PSF/SFPQ Is a Very Common Gene Fusion Partner in TFE3 Rearrangement–associated Perivascular Epithelioid Cell Tumors (PEComas) and Melanotic Xp11 Translocation Renal Cancersdoi:10.1097/PAS.0000000000000502An increasing number of TFE3 rearrangement-associated tumors, such as TFE3 rearrangement-associated ...
Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neu- roblastoma. Am J Surg Pathol 2009;33:1416-20.Mio T,Keisuke K,Kiyoshi G,et al.Perivascular epithelioid cell tumor with SFPQ/PSF-TFE3 gene fusion in a patient with advanced neuroblastoma.[J]...
Kidney: Renal cell carcinoma with t(X;1)(p11;p34) SFPQ/TFE3doi:10.4267/2042/68534Pedram ArganiARMGHM - Atlas Génétique des CancersArgani P. Kidney: Renal cell carcinoma with t(X;1)(p11;p34) SFPQ/TFE3. Atlas Genet Cytogenet Oncol Haematol. 2017; 21(8):306-307....
PSF/SFPQ Is a very common gene fusion partner in TFE3 rearrangement–associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers. Am J Surg Pathol 39: 1181–1196, 2015.PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated ...