White matterSpongiform degenerationCanavan disease (CD) is a neurodegenerative disorder characterized by the spongy degeneration of the white matter of the brain. Aspartoacylase (ASPA) gene mutation resulting enzyme deficiency is the basic cause of CD. Whether the ASPA defect in CD affects the spinal...
A previous study by Castronovo's research team found similar damage to gray matter volume in multiple brain regions of people with severesleep apnea. Improvements in gray matter volume appeared after three months of CPAP therapy. According to the authors, the two studies suggest that thewhite mat...
In 1994, the disease was conceived as a disconnection syndrome of the hemispheres from the brainstem, mainly due to a temporary or permanent deficit of the functions of the white matter. From 2005 on, the psychophysiological parameters relative to an emotional consciousness, albeit submerged, were ...
On June 20, the brain MRI indicated complete disappearance of the lesions on T1 and T2 sequences. However, the susceptibility-weighted imaging (SWI) unveiled dot-like paramagnetic signals in the corpus callosum and the bilateral gray-white matter junction, suggesting diffuse intracranial micro-...
Brain lesions—areas of brain tissue that show damage from injury or disease—are the biomarker most widely used to determine multiple sclerosis disease progression. But an innovative new study led by the University at Buffalo strongly suggests that the volume of white matter lesions is neither prop...
Centre for Neuroimaging Sciences, Department of Neuroimaging, Institute of Psychiatry, London, UK Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left front...
Bob Shahmardi was 4 years old when he developed a severe disease. Success rates with the disease were relatively low at that time, but his family was lucky to live in a community that was helpful when they didn’t have many resources and it was at that time that Make-A-Wish stepped ...
In our case, the disproportion between the severity of white matter damage and vascular changes does not support a cardinal role for ischemic mechanisms in leukoencephalopathy. Dentatorubropallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disease characterized clinically by the ...
Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In this study, we evaluate the effect of xenon
Over half of all reported traumatic brain injuries are the result of a motor vehicle accident. Other then the direct head impact itself, the sheer forces of the accident can cause the brain also to collide against the internal bone of the skull. In fact, when a moving head comes to a qu...