White matter injuryCognitive impairmentAlzheimer’s disease-related dementia (ADRD)Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and medical emphasis is to save lives and avoid disability during acute period of injury, a severe...
Alcohol use disorder has been associated with the development of neurodegenerative diseases, including Alzheimer’s disease (AD). However, recent studies demonstrate that moderate alcohol consumption may be protective against dementia and cognitive decli
Patients had a documented cognitive decline for 6 months or longer, brain computed tomography or magnetic resonance imaging (MRI) within 12 months before baseline that had normal results or demonstrated atrophy consistent with AD, no more than mild to moderate white matter disease, 2 or fewer ...
Abbreviations: ADNI: Alzheimer's Disease Neuroimaging Initiative; CWM: cerebral white matter; GM: cerebral cortical gray matter; ICC: intraclass correlations coefficient; IFT: infratentorial; MRI: magnetic resonance imaging; mTBI: mild TBI; NQ: NeuroQuant庐; SCN: subcortical nuclei; t0: time of ...
the process of aging. While a single unit of alcohol per day in a 50-year-old had negligible impacts associated with roughly half a year of aging, two or three units per day were associated with reductions in both gray and white matter. equating to roughly three and a half years of ...
摘要: Asymptomatic Cerebrovascular Disease. Clinical features of asymptomatic cerebrovascular disease: White matter lesion but not silent infarction related to non-specific complaints such as mild to moderate headache and dizziness FUJISHIMA Masatoshi 脳卒中 19(6), 485-488, 1997-12-25...
(n = 2), neurological conditions or MRI abnormalities e.g. multiple sclerosis, traumatic brain injury, ventriculomegaly, or severe white matter changes (n = 21), severe psychiatric problems (n = 9). See below for sources of information. The final sample consisted of 353 ...
Cultural factors, such as country or continent, influence the relationship between loneliness and mental health. However, less is known about how cultural
p75 neurotrophin receptor (p75NTR) signaling pathways substantially overlap with degenerative networks active in Alzheimer disease (AD). Modulation of p75NTR with the first-in-class small molecule LM11A-31 mitigates amyloid-induced and pathological tau-i
Models that closely resemble the alterations of brain development with loss of grey matter and diffuse white matter injury with ven- triculomegaly seen more frequently in the more preterm infant are less available. The P3 rat shares some similarities in terms of cortical neuronal, glial, and ...