Sepsis care bundles have become an integral part of the “Surviving Sepsis Campaign,” which aimed to improve survival from severe sepsis. These multifaceted interventions facilitate compliance with evidence-based guideline recommendations by creating two “bundles” that are sequentially completed at 6 ...
Conclusions: This QI project increased SLM in ED patients with severe sepsis, with associated increase in interventions (primarily crystalloid administration) and improvement in outcomes. Further studies are needed to evaluate the role of lactate as a trigger for interventions in the hemodynamic ...
Severe sepsis and septic shock are conditions associated with high morbimortality worldwide despite improvements in its management in the last two decades. It is of great interest for intensive care physicians to have the opportunity to use biomarkers for prediction of severity of disease and prognost...
This pathophysiologic similarity to sepsis raises the question whether thiamine has a role as an adjuvant sepsis therapy. A percentage of septic shock patients are thiamine deficient26,27,28 and thiamine administration improves their lactate clearance28. However, a randomized, double-blind trial of ...
The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has been shown to result in significantly lower mortality, its use remains controversial. Ther...
Impact of sepsis on CD4 T cell immunity J Leukoc Biol, 96 (2014), pp. 767-777 View in ScopusGoogle Scholar 15. L.E. Gleeson, F.J. Sheedy Metabolic reprogramming & inflammation: fuelling the host response to pathogens Semin Immunol, 28 (2016), pp. 450-468 View PDFView articleView in...
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly people and those with co-morbidities such as obesity and diabetes. Severe dis
There was no evidence of differences between the two groups in anaemia, malaria, sepsis, or haemoglobinuria serious adverse events (p>0·3; table 2). 500 (25%) of 1994 children in the co-trimoxazole group versus 498 (25%) of 1989 children in the no co-trimoxazole group had one or ...
Complement activation and the production of inflammatory mediators during the treatment of severe sepsis in humans. Scandinavian journal of infectious diseases. 1992;24(2):197-204.Dofferhoff ASM, De Jong HJ, Bom VJJ et al (1992) Complement activation and the production of inflammatory mediators ...
The Hepatosplanchnic Area Is Not a Common Source of Lactate Production (?): The authors reply: The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med 2001;29(2):256-61... De Backer, Daniel,Creteur, Jacques,Silva, Eliézer,... - 《Cr...