More importantly, we have shown that luminal concentrations of L-lactate relate to colorectal permeability in patients with severe sepsis [7], indicating pathophysiological relevance. In patients, i...
Inflammatory bowel disease is associated with changes in the mucosal barrier, increased intestinal permeability, and increased risk of infections and sepsis, but the underlying mechanisms are incompletely understood. Here, we show how continuous translocation of gut microbial components affects iron homeostas...
Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial commun...
Introduction: Poor lactate clearance in Emergency Department (ED) patients with severe sepsis is assdoi:10.1097/01.ccm.0000424703.34881.8bDettmer, MatthewHolthaus, ChristopherFuller, BrianCritical Care Medicine
Lactate, lactate clearance and outcome after cardiac arrest: A post‐hoc analysis of the TTM TTM ‐Trial Background Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out‐of‐hospital cardiac arrest, resul... Düring J.Dankiewicz J.Cronberg ...
The prognosis of septic patients with cirrhosis is worse compared to septic patients without cirrhosis. Early and accurate prognosis determination in patients with cirrhosis and sepsis is pivotal for guiding treatment decisions. The aim of this study was
were prospectively screened. eligibility criteria included a suspected or confirmed infection, two or more criteria for a systemic inflammatory response, and hypotension persisting after initial fluid challenge or blood lactate >4mmol/l [ 19 ]. exclusion criteria were pregnancy, age <18years, achieved...
Hyperfibrinolysis was defined as an FDP level ≥ 100 μg/ml, and the FDP/D-dimer ratio was used as a surrogate marker of fibrin(ogen)olysis [11]. Tissue hypoperfusion was defined as a blood lactate level ≥ 4 mmol/L based on the Surviving Sepsis Campaign Guidelines 2012 [24]...
In contrast to the acute effects of growth hormone (GH) on skeletal muscle protein synthesis, long-term GH treatment appears to have negligible effects on muscle mass. Despite this knowledge, little is known regarding the chronic effects of GH on skeleta
Fluorescence intensity detection was performed with excitation wavelength of 500 nm and emission wavelength of 525 nm using flow cytometry to detect reactive oxygen species (ROS). LDH and ATP assays Levels of lactate dehydrogenase (LDH) in the cell supernatants was measured using LDH assay kit (...