sepsisshockObjectives: This study aimed to compare the prognostic value of lactate level and lactate clearance at 6 hours after septic shock recognition. And, we performed it to determine lactate kinetics in the Sepsis-3 defined septic shock.Ryoo, Seung MokLee, JungBokLee, Yoon-SeonLee, Jae ...
Twitter Google Share on Facebook lactate dehydrogenase Thesaurus Medical Acronyms Encyclopedia Wikipedia Related to lactate dehydrogenase:lactate dehydrogenase test n.Abbr.LDH Any of a class of enzymes that catalyze the reversible interconversion of pyruvate and lactate, found predominantly in the liver, ki...
Given the limitations of lactate and the need for a surrogate marker and considering many physiological changes during sepsis and as the use of the L/A ratio will require further validation prior to clinical application, we conducted this study. The objective of this study was to find a valuabl...
[35], the blood lactate concentration in sepsis patients can reach more than 20 mm [36], and the lactate concentration in inflammatory tissues can even reach 40 mm [33]. lactic acid induces a decrease in the intracellular ph by entering the cytosol of cytotoxic cd8+t lymphocytes, thereby ...
one patient had an initial lactate value that was tested within 2 h from time zero of sepsis; thus, the serum lactate level on ICU day 1 was replaced by the initial lactate level, and imputation was done with the 2 patients. Because the serum lactate values on ICU days 1 or 3 were ...
Time Under Tension, Muscular Activation, and Blood Lactate Responses to Perform 8, 10, and 12RM in the Bench Press Exercise (Lactate clearance as final goal in resuscitation in severe sepsis and septic shock). MC-004: Depuracion de lactato como meta final en la resucitacion en sepsis severa...
The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has been shown to result in significantly lower mortality, its use remains controversial. Ther...
High throughput gene expression profiling is a valuable tool in providing insight into the molecular mechanism of human diseases. Hypoxia- and lactate metabolism-related genes (HLMRGs) are fundamentally dysregulated in sepsis and have great predictive po
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis. The present study demonstrated a novel role of lactate in HMGB1 lactylation and ace...
Kla has been found to also occur on nonhistone proteins. In terms of acute inflammation, abnormally elevated levels of lactate in the blood of sepsis patients can be taken up by macrophages, thereby increasing the Kla of intracellular HMGB1 protein91. This research also proved that lactate can ...