Serum free light chain (SFLC) testing is ordered to help detect, diagnose, and monitor plasma cell disorders (dyscrasias), including multiple myeloma, primary amyloidosis, and related diseases or to monitor the effectiveness of treatment. Light chains are proteins produced by plasma cells. Within a...
Serum protein electrophoresis (SPEP) plus serum free light chain (sFLC) testing: A sensitive panel for diagnosis of monoclonal gammopathy (MG)Van Hoeven, KWells, JAbadie, J
The serum-free light chain (SFLC) assay provides useful information in patients with plasma cell dyscrasias who secrete no or small quantities of monoclona... S Singhal,R Stein,E Vickrey,... - 《Blood》 被引量: 78发表: 2007年 Serum Free Light Chains in the Diagnosis and Monitoring of Pa...
Specifically, sFLC constitutes an MDE when the involved/uninvolved FLC ratio (i/u-FLC) exceeds 100 in smoldering multiple myeloma (SMM) patients. These guidelines specify that the proposed values are defined for measurements made with the Freelite reagent but without taking into account the ...
SFLC quantification is a useful tool for the diagnosis and follow-up of gammopathies such as amyloidosis and light chain myeloma. So far its quantification has never been studied in WM. We investigated whether SFLC quantification was correlated with monoclonal component value and established ...
The serum total light chain (sTLC) includes the light chain bound to a heavy chain as part of an intact immunoglobulin and the free light chain in serum (serum free light chain (sFLC)). In malignancies such as MM, tumor cells can produce a large number of sTLC and sFLC, which cannot...
Serum free light chain (SFLC) testing is ordered to help detect, diagnose, and monitor plasma cell disorders (dyscrasias), including multiple myeloma, primary amyloidosis, and related diseases or to monitor the effectiveness of treatment. Light chains are proteins produced by plasma cells. Within a...
This study aims to guide the integration of serum free light chain (sFLC) tests into clinical practice, including a new rapid test (Seralite (R)). Blood and urine analysis from 5573 newly diagnosed myeloma patients identified 576 light chain only (LCO) and 60 non-secretory (NS) cases. ...
Sethumadhavan, T
Retrospective audit of the freeliteTM serum free light chain (SFLC) assay: testing patterns, concordance with serum and urine electrophoresis/immunofixation and correlation with the N latex FLC assayAimsA retrospective audit of the Freelite SFLC assay was conducted to compare concordance with ...