Patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) were reported to demonstrate worse outcomes compared with patients with anti-myelin oligodendrocyte glycoprotein-a
One of the characteristic findings in NMOSD patients is the positivity of serum anti-aquaporin-4 autoantibody (AQP4-IgG) (Lennon et al., 2005). Although the positivity of AQP4-IgG is essential for NMOSD diagnosis and is included in the present diagnostic criteria, its exact pathological role ...
Lymphatic drainage in the central nervous system is regulated by meningeal lymphatic vasculature, and recurrent neuroinflammation alters lymphatic vessel remodeling. Patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) were reported to demonstrate worse outcomes ...
To evaluate the relationship between aquaporin-4 immunoglobulin G (AQP4-IgG) titer dynamics and relapse in neuromyelitis optica spectrum disorder (NMOSD), compare AQP4-IgG dynamics across different maintenance therapy strategies, and identify factors associated with AQP4-IgG titer seroreversion to ...
Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibody Diseases Ann. Neurol., 87 (2) (2020), pp. 256-266 CrossrefView in ScopusGoogle Scholar Gastaldi et al., 2022 M. Gastaldi, T. Foiadelli, G. Greco, S. Scaranzin, E. Rigoni, S...
Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4 autoantibodies (AQP4-IgG). Limited data is available on longitudinal c... Irena,Dujmovic,and,... - 《Journal of Neuroimmunology》 被引量: 50发表: 2011年 Pregnancy outcomes in aquaporin-4-positive neuromyelitis opti...
Thereafter, reaction with FITC anti-human IgG for 2nd antibody for 30 minutes, and 10,000 cells were read from Navius (Beckman Coulter). The mean fluorescence intensity (MFI) ratio , which is the ratio obtained by dividing the MFI value of both FITC and DsRed2 positive cells and DsRed2...
High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disordersSerum neurofilament light chainNeuromyelitis optica spectrum disordersMultiple sclerosisChineseBackground: Serum neurofilament light chain (sNfL) is a promising biomarker for neuromyelitis...
The discovery of anti-aquaporin-4 antibody (AQP4-Ab) enabled clinicians to diagnose NMOSD relatively earlier and more easily, as the AQP4-Ab can mediate the pathogenesis of NMOSD. Testing for AQP4-Ab in the serum of patients can play a crucial role in the diagnosis of NMOSD. Three-quarters...
Furthermore, a route between the para-arterial influx, interstitial fluid of the brain, cerebrospinal fluid and venous outflow has recently been discovered, entitled the glymphatic system because of the connection between glial cells and aquaporin-4-dependent paravascular pathways (mimicking a lymphatic...