内容提示: 南京犬爨博士学位论文英文题目C haracterizationofSERCA2basatargetproteino f者姓名科专业名称究方向导教师￡坚竖坚坐i望璺望亟i!§￡Q!￡i望塾坚磐垒坠!i卫Q 璺翌盥Q 磐曼王璐2011年5月作学研指 文档格式:PDF | 页数:152 | 浏览次数:27 | 上传日期:2018-10-22 08:27:49 | 文档星级:...
进一步证实姜黄素系通过直接结合并抑制脂肪肉瘤特异性高表达的肌浆网钙蛋白(SERCA2b)的活性,破坏了细胞内钙离子的稳态,从而引发了脂肪肉瘤细胞内质网应激.脂肪肉瘤细胞发生内质网应激的过程中,上调的CHOP蛋白作为转录因子转录出TRAIL-R2(DR5),继而活化其下游的Caspase8,引发上述的凋亡.SERCA家族是一种跨膜10次的阳离子...
SERCA2b mRNA decay involves interactions between -acting elements in its 3′-region and -acting destabilizing element in the decay and its interactions with the nuclear protein factors. The but not Ca. The decay was directional from 3′ to 5′, and involved a novel 35b GC rich domain ...
其后线粒体膜电位则出现明显降低.分子对接预测提示DHA与Thr316形成氢键相互作用,与Ile315则有疏水相互作用.进一步的生物膜干涉技术提示DHA与SERCA2b非突变蛋白结合信号良好,而与Ile315与Thr316位点突变后的SERCA2b突变蛋白结合信号较差.结论DHA可直接与SERCA2b的Ile315与Thr316位点结合,并通过线粒体途径诱导结肠癌HCT-...
结论DHA可直接与SERCA2b的Ile315与Thr316位点结合,并通过线粒体途径诱导结肠癌HCT-116细胞凋亡。 关键词:二氢青蒿素 肌浆/内质网钙ATP酶 结直肠肿瘤 分类号:R34[医药卫生—基础医学]参考文献: 二级参考文献: 耦合文献: 引证文献: 二级引证文献: 同被引文献: 相关期刊文献: ...
为了验证USP25可以通过稳定SERCA2a来改善心肌肥厚,作者构建了携带USP25、SERCA2a或zsGreen的重组AAV-9载体,并通过尾静脉注射给小鼠。USP25-/-小鼠USP25表达的恢复减弱了Ang II诱导的心肌肥厚、纤维化和心功能障碍。在野生型和USP25-/-小鼠...
In human platelets, two different SERCA isoforms, with molecular masses of 100 and 97 kDa, are expressed in two distinct Ca2+ stores [33], [34], [35], [36], [37], [38], [39]. The 100 kDa isoform has been identified as SERCA 2b, and is inhibited by low concentrations of TG [...
Calcium cycling induced by the SERCA2b–RyR2 pathway in beige fat cells allows for thermogenic activity independent of UCP1. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remai
Interestingly, ERp57 does not affect the activity of SERCA 2a or SERCA 2b mutants lacking the CR1 binding site. Overexpression of CR1 domains that disrupt the interaction of CRT with ERp57 behave as dominant negatives in the Ca[sup2+] oscillation assay. Our results suggest that ERp57 ...
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