Conversely, enhanced Ca2+ cycling by activation of 伪1- and/or 尾3-adrenergic receptors or the SERCA2b-RyR2 pathway stimulates UCP1-independent thermogenesis in beige adipocytes. In the absence of UCP1, beige fat dynamically expends glucose through enhanced glycolysis, tricarboxylic acid metabolism ...
Calcium cycling induced by the SERCA2b–RyR2 pathway in beige fat cells allows for thermogenic activity independent of UCP1. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remai
Conversely, enhanced Ca 2+ cycling by activation of α1- and/or β3-adrenergic receptors or the SERCA2b-RyR2 pathway stimulates UCP1-independent thermogenesis in beige adipocytes. In the absence of UCP1, beige fat dynamically expends glucose through enhanced glycolysis, tricarboxylic acid metabolism...
Abnormalities in calcium release have been related to “leakiness” of the Ca2+ release channel, ryanodine receptor 2 (RyR2) (18), while down-regulation of the SR/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) impairs reuptake of Ca2+ from the cytoplasm and the myofilaments into the SR ...
Calcium cycling induced by the SERCA2b–RyR2 pathway in beige fat cells allows for thermogenic activity independent of UCP1. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remai