Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or Protein to identify regions of similarity that may be a consequence of ...
Alignment-free (AF) sequence comparison is attracting persistent interest driven by data-intensive applications. Hence, many AF procedures have been proposed in recent years, but a lack of a clearly defined benchmarking consensus hampers their performanc
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. The strength of these methods makes them particularly useful for next-generati...
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. The strength of these methods makes them particularly useful for next-generati...
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MegAlign Pro sequence alignment software performs sequence alignments quickly and easily, then guides you through the post-alignment process.
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We also trained an MSA-free version of AlphaFold2, denoted by AlphaFold2-Single, by only using the single sequences as input. To evaluate the accuracy of HelixFold-Single and other methods, we utilized a commonly used metric, that is, the template modelling score (TM-score)18. Figure 2 ...
In an analysis of complete polyprotein sequences from the viral family Flaviviridae, the CGR method was able to cluster members of major viral groups together, but relations within groups were not well resolved in comparison to an alignment-based phylogeny. We applied the method to members of ...
Alignment-free approaches to sequence comparison can be defined as any method of quantifying sequence similar- ity/dissimilarity that does not use or produce alignment (assignment of residue–residue correspondence) at any step of algorithm application. From the start, such restric- tion places the ...