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Alignment-free approaches to sequence comparison can be defined as any method of quantifying sequence similarity/dissimilarity that does not use or produce alignment (assignment of residue–residue correspondence) at any step of algorithm application. From the start, such restriction places the alignment-...
Free Downloads of CodonCode Aligner for DNA sequence assembly, alignment, contig editing, and mutation detection. Free trial for Windows and Mac OS X.
DNA sequence assembly, sequence alignment, contig editing, and mutation detection software for Windows and Mac OS X. View & edit sequence assemblies.
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. The strength of these methods makes them particularly useful for next-generati...
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MegAlign Pro sequence alignment software performs sequence alignments quickly and easily, then guides you through the post-alignment process.
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Rapid methods for alignment-free sequence comparison make large-scale comparisons between sequences increasingly feasible. Here we study the power of the statistic D2, which counts the number of matching k-tuples between two sequences, as well as D2*, which uses centralized counts, and D2S, ...