(with and without sepsis). B, Underlying cause of death in patients with sepsis. The cohort included 568 patients who died in the hospital or were discharged to hospice, of whom 300 had sepsis at some point during hospitalization. Per Centers for Disease Control and Prevention guidelines, the...
Rhee C, Jones TM, Hamad Y, et al; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open. 2019;2(2):e187571. doi:10.1001/jama...
2. While it can impact individuals of all ages, sepsis poses a particularly grave threat to children3. In 2017, approximately 20.3 million new cases of sepsis and 2.9 million deaths occurred in children under five years of age, where the burden of sepsis is greater in low-resource settings...
The role of caspases and their inhibitors in sepsis to cause and protect from apoptosis, inflammation, pyroptosis and necroptosis has been summarized in Figure 5. Besides the conventional strategies utilizing the caspase inhibitors and gene knockout mice to block apoptosis, several other therapeutic reg...
which not only define their role in pathophysiology but also help implement potential therapeutic strategies against this deadly clinical syndrome. We therefore aim to revisit and update our thinking toward the role of caspases in sepsis in terms of inflammation, cellular apoptosis and organ injuries....
Facts Sepsis leads to uncontrolled inflammatory response with immunosuppression. Immune cell alteration induced by uncontrolled apoptosis is a major cause of profound immunosuppression. Therapeutic perspectives targeting apoptosis through various strategies could improve survival in sepsis. ...
Conclusion: We found a high prevalence of urosepsis among patients who have un- dergone TRUS prostate biopsy, and identified two significant risk factors. The results of this study highlight the importance of implementing strategies for prevention of urosepsis following TRUS pro...
Reliable sepsis surveillance is essential given its high burden, the proliferation of treatment and prevention initiatives, and new national sepsis quality measures. Identifying sepsis using consistent clinical criteria through EHR data, rather than relying on explicit clinical diagnoses or hospital coders,...
Understanding the interplay between autophagy, cell death, and inflammation in sepsis can inform therapeutic strategies. For example, enhancing autophagy can help control excessive inflammation and improve immune function. Conversely, inhibiting excessive autophagy may prevent autophagic cell death and tissue ...
In sepsis the effectiveness of antibacterials in the bloodstream is limited by different factors. The optimal strategies and the effectiveness of antibacterial treatment in sepsis depend on bacterial forms of sepsis-causing bacteria, types of sepsis, pathogen sensitivity to antibacterials, microbe respiratio...