Prevention and drug development The prospects of scientists developing new antibiotics as fast as bacteria develop resistance are poor. Therefore, other measures have been undertaken, including educating the pu
This requirement presents great therapeutic challenges owing to the need for persistent and nearly complete caspase blockade. Ample number of literature supports the notion that caspases have several other functions apart from their role as cell-death proteases and regulators of inflammation, which ...
Apoptosis is a tightly regulated form of cell death that is vital in both embryo implantation and development and turnover of tissues during maturation32. During sepsis-induced immunosuppression, apoptosis plays a pivotal role in the selection of immune cell populations and maintenance of functional im...
Sepsis is a life-threatening illness that occurs due to an abnormal host immune network which extends through the initial widespread and overwhelming inflammation, and culminates at the late stage of immunosupression. Recently, interest has been shifted toward therapies aimed at reversing the accompanyi...
Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz M, Gastmeier P, Reinhart K (2019) Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence ...
prior work indicates that using a preventability measure with imperfect reliability may potentially overestimate the number of preventable cases.46Our finding that only 1 in 8 sepsis-associated deaths is potentially preventable may therefore be conservative and challenges the overly simplistic assumption tha...
Sepsis is a major reason for preventable hospital deaths. A cluster-randomized controlled trial on an educational intervention did not show improvements of sepsis management or outcome. We now aimed to test an improved implementation strategy in a second
One of basic challenges in the treatment of sepsis caused by Gram-negative bacteria is the release of endotoxin (lipopolysaccharide, LPS) from bacteria due to killing by antibiotics and/or phagocytosis in the liver and the spleen. An effective treatment must comprise the neutralization of endotoxins...
involving forms of local capacity-building along the way on methods of organising and storing hospital records and entering them into excel spreadsheets. In this context (as in many others), much of the facility-based data could not be interpreted at face value as facts; but rather, as artefa...