Apoptosis is a tightly regulated form of cell death that is vital in both embryo implantation and development and turnover of tissues during maturation32. During sepsis-induced immunosuppression, apoptosis plays
Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644–55. CASPubMedGo...
Try Britannica Premium for free and discover more. Subscribe Prevention and drug development The prospects of scientists developing new antibiotics as fast as bacteria develop resistance are poor. Therefore, other measures have been undertaken, including educating the public about the proper use of ant...
intervention hospitals showed higher proportion of adequate initial antimicrobial therapy and de-escalation within 5 days. A survey among involved clinicians indicated lacking resources for quality improvement. Therefore, quality improvement programs should include all elements of sepsis guidelines and provide...
(with and without sepsis). B, Underlying cause of death in patients with sepsis. The cohort included 568 patients who died in the hospital or were discharged to hospice, of whom 300 had sepsis at some point during hospitalization. Per Centers for Disease Control and Prevention guidelines, the...
caused by the underlying infection [3]. Sepsis is associated with a mortality rate of 25–30% and mortality due to septic shock is 50–85% [4,5]. Empiric antimicrobial therapy is the cornerstone of the treatment [6]. Current guidelines recommend starting antibiotic therapy within one hour ...
Sepsis is a life-threatening condition caused by an excessive inflammatory response to an infection, associated with high mortality. However, the regulatory mechanism of sepsis remains unclear. In this study, bioinformatics analysis revealed the novel ke
Table 1 Nutrition facts of WMPP Full size table Experimental design After a week of adaptive feeding, they were completely randomized into control group (7 mice) and SIM group (36 mice). To ensure the balance of energy intake, the food supply of the control mice was based on the average...
Conclusion: We found a high prevalence of urosepsis among patients who have un- dergone TRUS prostate biopsy, and identified two significant risk factors. The results of this study highlight the importance of implementing strategies for prevention of urosepsis following TRUS pro...
Rhee C, Jones TM, Hamad Y, et al; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open. 2019;2(2):e187571. doi:10.1001/jama...