Gene structure of PACO1, a petal senescence-related gene from Phalaenopsis encoding peroxisomal acyl-CoA oxidase homolog - YY, PL - 1997Do YY, Huang PL (1997) Gene structure of PACO1, a petal-senescence-related gene from Phalaenopsis encoding peroxisomal acyl-CoA oxidase homolog. Biochemistry ...
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer Aging-related cancer incidence remains not fully understood. Here, the authors depict a progressive process of senescence in murine mammary stem cells at single-cell resolution, which is governed by the tr...
Zentgraf U, Jobst J, Kolb D, Rentsch D (2004) Senescence-related gene expression profiles of rosette leaves of Arabidopsis thaliana: leaf age versus plant age. Plant Biol (Stuttg) 6:178–183 Article CAS Google Scholar Download references Authors’ contributions CYC conceived and designed the ex...
In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting thes
Senescent cells are characterized by a persistent DNA damage response (DDR), including chronic ATM (Ataxia Telangiectasia mutated) and ATR (Ataxia Telangiectasia and Rad3 related) kinase signaling which ultimately invokes cell cycle arrest and senescence through activation of the p53/p21 and p16/pRb ...
Besides the hyperactivation of PI3K/AKT and amplification of AR signaling, other mechanisms driving the progression of PCa include the activation of activator protein-1 (AP-1) mediated gene expression [14]. AP-1 transcription factors (TF) such as JUN, were initially considered as proto-oncogenes...
ATM- and Rad3-related CDC25: Cell division cycle 25 cGAS: Cyclic GMP-AMP synthase DDR: The DNA damage response DSBs: DNA double-strand breaks HCMV: Human cytomegalovirus HR: Homologous recombination IKK: IκB kinase MDC1: Mediator of DNA damage checkpoint protein 1 MRN: MRE11...
(ATM- and Rad3-related), both of which are the main kinases of the DDR [25]. ATM is largely engaged in DSB repair, whereas ATR is primarily involved in the recognition of ssDNA wrapped by RPA [26] (Fig.1). Although ATM and ATR recognize distinct forms of DNA damage, both are ...
“replicative senescence,” yet remain viable. Cellular senescence has come to be associated primarily with aging and age-related diseases. However,cellular senescenceis also an important part of severalbiological processesincludingembryogenesis(Rajagopalan and Long, 2012), pregnancy (Velarde and Menon, ...
Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during agin...