This review highlights the modern concepts of aging at the cellular level. Particular attention is given to the mesenchymal stromal/stem cells (MSCs), which are involved in tissue homeostasis maintenance. Age-related MSC function alterations in tissue niches including immunomodulatory activity, ...
Zhang, D. Y., Wang, H. J. & Tan, Y. Z. Wnt/β-catenin signaling induces the aging of Mesenchymal stem cells through the DNA damage response and the P53/P21 pathway.PLoS One6, e21397 (2011). ArticleCASPubMedPubMed CentralGoogle Scholar Sarkisian, C. J. et al. Dose-dependent oncog...
Metformin inhibits chronic kidney disease-induced DNA damage and senescence of mesenchymal stem cells. Aging Cell 20, e13317 (2021). CAS PubMed PubMed Central Google Scholar Wang, Y. et al. Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat. Commun....
Z. Wnt/β-catenin signaling induces the aging of Mesenchymal stem cells through the DNA damage response and the P53/P21 pathway. PLoS One 6, e21397 (2011). Article CAS PubMed PubMed Central Google Scholar Sarkisian, C. J. et al. Dose-dependent oncogene-induced senescence in vivo and ...
In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to their easy acquisition and cultivation, strong regenerative capacity, multi-directional differentiation abilities, and immunomodulatory effects. Autologous MSCs are better applicable compared with allogeneic MSCs in cli...
delaying cellular senescence or increasing the number of stem cells may greatly delay senescence. In this regard, stem cell-based cell therapies have been proposed for the treatment of senescence. Among them, MSCs as a kind of pluripotent stromal cells that have the potential of unlimited prolifera...
Here, we share our current understanding of the role of cellular senescence in AKI, along with examples of the application of mesenchymal stem cells (MSCs) for targeting this disorder during its treatment.doi:10.1111/jcmm.16163John Wiley & Sons, LtdJournal of Cellular and Molecular Medicine...
However, toxic effects of p-cresol on mesenchymal stem cells have not been elucidated. Thus, we aimed to investigate whether p-cresol induces senescence of mesenchymal stem cells, and whether melatonin can ameliorate abnormal autophagy response caused by p-cresol. We found that p-cresol ...
Background Bone marrow derived mesenchymal stem cells (bmMSCs) are multipotent cells that can differentiate into diverse cell types, including cardiomyocytes. BmMSC-based transplantation is capable of repairing acute and chronic myocardial infarction. Prior to the transplantation, MSCs are usually induced ...
Metformin inhibits chronic kidney disease-induced DNA damage and senescence of mesenchymal stem cells. Aging Cell 20, e13317 (2021). Article CAS PubMed PubMed Central Google Scholar Simons, J. The $10 billion pill. Fortune 147, 58–62 (2003). PubMed Google Scholar Assmus, B. et al....