Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it
(Heeschen et al., 2004;Roobrouck et al., 2008).As MSCs are morphologically and functionally similar to BM-MSCs,MSCs generated from induced pluripotent stem cells (iPSCs)may present an alternative that could overcome these limitations of BM-MSCs (Lian et al.,2010).iPSC-MSCs not only express...
Mesenchymal stem cells (MSC) have generated a great amount of enthusiasm over the past decade as a novel therapeutic paradigm for a variety of diseases. Currently, MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating...
Bone-marrow-derived-mesenchymal-stem-cells-骨髓源性间充质干细胞 热度: Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis 热度: Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord...
Stem cells A subset of cells that has a self-renewing capacity and under appropriate conditions can give rise to several mature cell lineages. Mesodermal lineage In animals with three tissue layers, the mesoderm is the middle layer of tissue, between the ectoderm and the endoderm. In vertebrates...
Mesenchymal stem cells (MSCs) suppress alloantigen-induced T-cell functions in vitro and infusion of third-party MSCs seems to be a promising therapy for graft-versus-host disease (GVHD). Little is known about the specificity of immunosuppression by MSCs, in particular the effect on immunity to...
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells, actively contribute to the formation of the tumour microenvironment, wherein they are converted into tumour-associated MSCs (TA-MSCs). TA-MSCs regulate tumour growth, metastasis and responses to chemotherapy and radiotherapy by ...
Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show considerable promise for use in cartilage and intervertebral disc (IVD) repair. This review article focuses on stem cell-based therapeutics for cartilage and IVD repair...
6 reagents referenced in Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage.
METHODS: Rat bone marrow mesenchymal stem cells were isolated from the bilateral tibial and femoral bones by the method of whole bone marrow, then purified and passaged by attachment method. The morphology and features of bone marrow mesenchymal stem cells were observed, the growth curve was ...