Nanomedicines suffer from poor drug loading and uncontrolled ‘burst release’ after administration. Combining prodrug strategies with nanostructured carriers can help to overcome these limitations by improving diffusion through biological barriers, enzy
Combining prodrug strategies with nanostructured carriers can help to overcome these limitations by improving diffusion through biological barriers, enzymatic activation of the lipid conjugate in the diseased area, drug protection, pharmacokinetics and biodistribution, intracellular delivery and/or targeting ...
The prodrugnanoassemblies could be further refined by PEGylation and PDAC-specificpeptide ligand for preclinical studies. In vitro cell-based assaysshowed that not only were GEM nanoparticles superior to free GEM butalso the decoration with PDAC-homing peptide facilitated the intracellularuptake of ...
Using our developed PUFAylation technology, the GEM prodrug was able to spontaneously self-assemble into colloidal stable nanoparticles with sub-100 nm size on covalent attachment of hydrophobic linoleic acid via amide linkage. The prodrug nanoassemblies could be further refined by PEGylation and PDAC...
To overcome this, the lipid prodrug YF8-OA was synthesized by linking oleic acid (OA) to YF8 through an ester bond. Although YF8-OA could self-assemble into unique nanostructures in water, it was not sufficiently stable. To enhance the stability of YF8-OA lipid prodrug nanoparticles (LPs...
Interestingly, the lengths of the disulfide bond affected the drug release, cytotoxicity, pharmacokinetic characteristics, in vivo biodistribution and antitumor efficacy of prodrug NPs. To be more specific, all three PPT prodrugs could self-assemble into uniform nanoparticles (NPs...
A redox-responsive DTX prodrug synthesized in our laboratory was used to prepare DTX prodrug self-assembled nanoparticles (DSNPs) with the method of nanoprecipitation. This study aimed at optimizing the formulation to develop stable preparation for the delivery of DTX. Single-factor test was used ...
In this work, polymeric prodrug nanoparticles with spontaneous, self-assembled particle formation ability and mucoadhesive properties were used to reduce the severe side effect of MMC. The particles were synthesized by conjugation of MMC and CYS with succinated PVA combined with self-assembled particle...
self-assembling peptides; magnetic nanoparticles; cell-penetrating peptides; triple negative breast cancer1. Introduction Cancer is one of the most lethal diseases and tumor-related morbidity and mortality have significantly increased in recent years with breast cancer (BC) being the most frequent ...
NanoparticlesSustained and controlled releaseDrug deliveryDespite the great efficacy of indomethacin (IND) as an anti-inflammatory agent, its clinical translation has been obstructed by the water insolubility, severe side effects, and exceedingly low bioavailability. Indomethacin prodrug-based nanoparticles (...