Nanomedicines suffer from poor drug loading and uncontrolled ‘burst release’ after administration. Combining prodrug strategies with nanostructured carriers can help to overcome these limitations by improving diffusion through biological barriers, enzy
Combining prodrug strategies with nanostructured carriers can help to overcome these limitations by improving diffusion through biological barriers, enzymatic activation of the lipid conjugate in the diseased area, drug protection, pharmacokinetics and biodistribution, intracellular delivery and/or targeting ...
Self-Assembled Gemcitabine Prodrug Nanoparticles Show Enhanced Efficacy against Patient-Derived Pancreatic Ductal Adenocarcinoma 来自 Semantic Scholar 喜欢 0 阅读量: 158 作者:L Wu,F Zhang,X Chen,J Wan,H Wang 摘要: Effectivenew therapies for pancreatic ductal adenocarcinoma (PDAC)are desperately needed ...
In this study, Ru-1 loaded TPP-PEG-biotin self-assembled nanoparticles (Ru-1@TPP-PEG-biotin) was used in a novel combination therapy that simultaneously co-targeted GRP78 and lysosome as a new anti-cancer therapeutic strategy. Compared to previous approach based on encapsulation of doxorubicin ...
(CSAN) is being developed. Many active components of TCM possess self-assembly properties, allowing them to form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) are also present in TCM decoctions, and they are closely linked to the therapeutic effects of these ...
3.3. Characterization of the pH-responsive self-assembled nanodrugs 3.3.1. Shape and size of nanoparticles at different pH The pH-responsive self-assembly properties of ZD-B and ZD-E-1 were assessed from three aspects. We observed the shape and size by TEM (Hitachi) and SEM (Hitachi) (Fig...
The purity of the prodrug is 97.3%, as determined by reversed-phase HPLC (Fig. 1A). The product was characterized by proton nuclear magnetic resonance Conclusion In conclusion, ART dimer phospholipid (Di-ART-GPC) prodrug was successfully prepared and assembled into liposomes in aqueous medium ...
Self‐Assembled Nanoparticles with Dual Effects of Passive Tumor Targeting and Cancer‐Selective Anticancer Effects Nanoparticular drug delivery systems may help to overcome the limitations of conventional chemotherapy. They have been reported to improve the specificity ... YW Won,SM Yoon,KS Lim,... ...
Self-assembled lipid–prodrug nanoparticles Article28 June 2023 Determining the critical quality attribute for the delivery of α–mangostin by β–cyclodextrin-based nanoparticles in cancer treatment Article14 July 2023 Introduction Over the past few decades,trans-resveratrol (3,4′,5-trihydroxy-trans-...
Chunbai He1 & Wenbin Lin1 Nanoscale coordination polymers (NCPs) are self-assembled from metal ions and organic bridging ligands, and can overcome many drawbacks of existing drug delivery systems by virtue of tunable compositions, sizes and shapes, high drug loadings, ease of surface modification...