This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety. The key to realizing the full potential of these vaccines is...
Efficient inhibition of RNA self-primed extension by addition of competing 3′-capture DNA-improved RNA synthesis by T7 RNA polymerase. Nucleic Acids Res. 2019;47:e118. CAS PubMed PubMed Central Google Scholar Kariko K, Muramatsu H, Ludwig J, Weissman D. Generating the optimal mRNA for ...
This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety. The key to realizing the full potential of these vaccines is...
Exploratory biomarker analyses showed decreased circulating tumor DNA (ctDNA) in patients with prolonged OS. Although small study size limits statistical and translational analyses, the increased OS observed in MSS-CRC warrants further exploration in larger randomized studies....
Keywords vaccine RNA influenza replicon trivalent alphavirus H1N1 DNA Sorry, something went wrong. Please try again and make sure cookies are enabledCited by (0)5 These authors contributed equally to this work. 6 Present address: SR Kymab, Cambridge, UK ...
Formation and characterization of pDNA-loaded alginate microspheres for oral administration in mice(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING) Alginate, a natural polysaccharide, was explored in this study as an oral delivery vehicle of a mammalian expression vector into the murine intestinal muc...
Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, circular RNA, antisense RNA, self-amplifying RNA, DNA, and gene editing therapeutics. Arcturus...
First of all, mRNA, which is delivered into the host cell, does not need to be transported into the nucleus as happens in the case of DNA. It is translated into protein in the cytoplasm [25] that does not alter the physiological state of the cell. This averts any possible intervention ...
K,Kim, J. S.Label-Free and Self-Signal Amplifying Molecular DNA Sensors Based on Bioconjugated Polyelectrolytes. Advanced Functional Materials . 2007Lee K,Povlich LK,Kim J.Label-free and self-signal amplifying molecular DNA sensors based on bioconjugated polyelectrolytes. Advanced Functional Materials...
Lee, Kangwon,Rouillard, Jean-Marie,Kim, Bong-Gi,Gulari, Erdogan,Kim, Jinsang.Conjugated polymers combined with a molecular beacon for label-free and self-signal-amplifying DNA microarrays.Advanced Functional Materials. 2009L. Kangwon,,R. Jean-Marie,K. Bong-Gi,G. Erdogan,K. Jinsang....