Negative symptoms in schizophrenia may be classified as primary or secondary. Primary negative symptoms are thought to be intrinsic to schizophrenia, while secondary negative symptoms are caused by positive symptoms, depression, medication side-effects, social deprivation or substance abuse. Most of the ...
In vitro secondary pharmacology assays are an important tool for predicting clinical adverse drug reactions (ADRs) of investigational drugs. We created the Secondary Pharmacology Database (SPD) by testing 1958 drugs using 200 assays to validate target-AD
B.I. Turetsky, in The Neurobiology of Schizophrenia, 2016 Neurobiology of MMN Converging evidence from magnetoencephalography, ERP source modeling, fMRI, and PET imaging suggests that MMN is generated bilaterally in the primary and secondary auditory cortices, with perhaps a later contribution from ...
Schizophrenia is phenomenologically heterogenous and includes multiple psychological domains e.g., "negative" (or "deficit") symptoms. The importance of the negative symptom complex includes long-term outcome. Carpenter et al highlighted the inherent difficulties in distinguishing between primary negative (...
Emergence of symptoms of Tourette's syndrome during fluvoxamine treatment of obsessive-compulsive disorderBr J Psychiatry. 1994; 164:839-841 Crossref PubMed Google Scholar 54. Finelli, P. ∙ Pueschel, S.M. ∙ Padre-Mendoza, T. ... Neurological findings in patients with the fragile-X syndr...
All MAFS subscales correlated positively and significantly with cognitive-behavioral skills and adaptive regulatory strategies and negatively with depressive symptoms and suicidal ideation. Conclusion The Spanish MAFS translation is a valid and reliable self-report measure to assess three domains of ...
We probed the potential association and eventual stability of neuropsychological profiles and serum BDNF concentrations with lifetime suicide ideation and attempts (LSI and LSA, respectively) in individuals with schizophrenia (SCZ) and schizoaffective disorder (SCA) in a 2-year follow-up st...
Default Mode Network Connectivity as a Function of Familial and Environmental Risk for Psychotic Disorder Background Research suggests that altered interregional connectivity in specific networks, such as the default mode network (DMN), is associated with cognitive and psychotic symptoms in schizophrenia. ...
Kirkbride JB, Fearon P, Morgan C, Dazzan P, Morgan K, Tarrant J, Lloyd T, Holloway J, Hutchinson G, Leff JP, Mallett RM, Harrison GL, Murray RM, Jones PB: Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-centre AeSOP study. Arch Gen...
STUDY I: Data from 49 people with symptoms of depression, anxiety and/or stress in the mild-to-moderate range were used to examine the reliability and construct validity of a new measure of MHSE, the Mental Health Self-efficacy Scale (MHSES). STUDY II: We conducted a secondary analysis ...