Others, especially Goodale and Slater, Stern and Moore, have implied such a factor by treating patients with liver or vitamins. The experiments on animals of Mellany and of Zimmerman have suggested a similar possibility. It must be admitted, however, that the actual evidence favoring this point...
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals...
Exclusion criteria were primary or secondary progressive multiple sclerosis; hereditary neurologic diseases; pregnancy; pulmonary, cardiac, renal, or liver dysfunction; abnormal platelet or white blood cell counts; active infection; prior treatment with alemtuzumab or mitoxantrone; or use of natalizumab ...
We performed sensitivity analyses using cumulative averages of intake of PUFA from available cohorts (the NHS and HPFS); however, the results remain unchanged so they are not presented. In secondary analysis, we modeled fat subtypes as a percentage of total energy using nutrient-density models ...
Research on the markers of immunoregulatory response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of leptin, fibronectin, and UCHL1 concentrations as potential biomarkers of a relapsing–remitting type of MS (RRMS). Surface Plasmon Resonance Ima...
Helicobacter pylori (H. pylori) is a common human pathogen which has been implicated in the pathogenesis of peptic ulcer disease and stomach cancer. H. pylori colonizes the stomach of about half the globe’s population, and its decline in the developed w
developed CNS lesions, even in the absence of sensitization with myelin peptides [69]. Although the lung and liver were also infiltrated by cells in this study [69], they did not demonstrate pathology or symptoms, suggesting the CNS is particularly susceptible to the effects of dysregulated GM...
liver function (ALT greater than 1.5 times the upper limit of the normal range) within one month of randomisation. That blood test may be repeated in the case of initial abnormal results; if the levels return to normal, the patient may then be included in the study. Renal insufficiency (...
Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting the frontal and temporal lobes. Genome-wide association studies (GWAS) on FTD identified only a few risk loci. One of the possible explanations is that FTD is clinicall
These findings, derived from the analysis of the UK Biobank and representing an unprecedented approach for this inquiry, warrant further exploration and integration in future research. Keywords: multiple sclerosis;diet;autoimmune diseases;UK Biobank...