Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals...
Exclusion criteria were primary or secondary progressive multiple sclerosis; hereditary neurologic diseases; pregnancy; pulmonary, cardiac, renal, or liver dysfunction; abnormal platelet or white blood cell counts; active infection; prior treatment with alemtuzumab or mitoxantrone; or use of natalizumab ...
We performed sensitivity analyses using cumulative averages of intake of PUFA from available cohorts (the NHS and HPFS); however, the results remain unchanged so they are not presented. In secondary analysis, we modeled fat subtypes as a percentage of total energy using nutrient-density models ...
Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting the frontal and temporal lobes. Genome-wide association studies (GWAS) on FTD identified only a few risk loci. One of the possible explanations is that FTD is clinically, pathologically, and genetically heterogeneous. ...
neuroinflammation and MS risk [2]. Interestingly, the liver recently emerged as an additional distant organ influencing brain health, with the liver–brain axis also being studied in the context of MS. This evidence encourages the study of diet as a modifiable risk factor for the neurological ...
The first step occurs mainly in the liver, while the second step occurs principally in the kidneys. However, other tissues including various epithelial cells, immune cells, and the parathyroid gland also possess the ability to perform this hydroxylation [59]. The major circulating form of vitamin...
liver function (ALT greater than 1.5 times the upper limit of the normal range) within one month of randomisation. That blood test may be repeated in the case of initial abnormal results; if the levels return to normal, the patient may then be included in the study. Renal insufficiency (...
In addition to the well-known detrimental properties of reactive oxygen species (ROS), gasotransmitters (e.g., nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)) are also thought to play an important role in SSc. Accordingly, the diverse physiologic actions of NO and CO...