(A) UMAP visualization of ETP and fetal liver hematopoietic stem cells (HSCs) and early progenitors. NMP, neutrophil-myeloid progenitor; MEMP, megakaryocyte/erythrocyte/mast cell progenitor. (B) The same UMAP colored by organ (liver in blue, thymus in yellow/red). (C) UMAP visualization of d...
对各个Cluster进行Marker基因鉴定发现细胞分型与已知Marker基因很吻合,如内皮细胞 (endothelial cell)的Kdr基因,肾小囊脏层细胞(podocytes)的Nphs1和Nphs2基因,亨式上升环细胞(ascending loop of Henle)的Slc12a1基因,以及远曲小管(distal convoluted tubule)的Slc12a基因。 免疫细胞和内皮细胞虽然被上皮细胞所分开,但...
近日,华中科技大学同济医学院附属协和医院胡德胜团队联合中国中医科学院西苑医院刘玥团队在Science Bulletin上发表了题为“Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1hineutrophil in myocardial ischemia-reperfusion injury”的封面文章,该文章首次绘制了缺血再灌...
(A) UMAP visualization of ETP and fetal liver hematopoietic stem cells (HSCs) and early progenitors. NMP, neutrophil-myeloid progenitor; MEMP, megakaryocyte/erythrocyte/mast cell progenitor. (B) The same UMAP colored by organ (liver in blue, thymus in yellow/red). (C) UMAP visualization of d...
【13】2022年11月9日,北京大学第一医院肿瘤转化研究中心张宁团队、北京大学生物医学前沿创新中心(BIOPIC)张泽民团队与北京大学人民医院肝胆外科朱继业团队紧合作在Nature杂志在线发表题为“Liver tumor immune microenvironment subtypes and neutrophil heterogeneity”的研究论文,这项研究分析了189个肝癌患者和小鼠模型样本的细...
Functional blood cell analysis by label-free biosensors and single-cell technologies ZoltánSzittner, ...RobertHorvath, inAdvances in Colloid and Interface Science, 2022 4.1Neutrophil granulocytes The name granulocyte refers to the densely granulated cytoplasm of these cells. Subgroups of thegranulocytesar...
1 Neutrophil homeostasis Neutrophils, also called neutrophil granulocytes, are the most abundant white blood cell type in mammals. They form together with basophiles and eosinophils a polymorphonuclear cell family called PMNs (Roitt et al., 2001). They originate like most of blood stream cells from...
【13】2022年11月9日,北京大学第一医院肿瘤转化研究中心张宁团队、北京大学生物医学前沿创新中心(BIOPIC)张泽民团队与北京大学人民医院肝胆外科朱继业团队紧合作在Nature杂志在线发表题为“Liver tumor immune microenvironment subtypes and neutrophil heterogeneity”的研究论文,这项研究分析了189个肝癌患者和小鼠模型样本的细...
通过抗肿瘤或促肿瘤极化,这些细胞可以影响肿瘤生物学的多个方面,并影响其对常规疗法和免疫疗法的敏感性。scRNA-seq分析可以揭示广泛的中性粒细胞异质性,有助于理解其多效性作用。该综述总结了肿瘤相关中性粒细胞(tumor-associated neutrophil,TAN)生物学的最新数据和模型,重点关注了响应肿瘤内在信号的细胞多样性。
Oct. 31, 2024 No Comments Previous studies have shown that NETosis, a specialized form of neutrophil-specific cell death, is involved in the pathogenesis of diabetes.Read More S1PR4 inhibition prevents disease progression in murine Alport syndrome Oct. 30, 2024 No Comments The knockout of ...