technique, we showed that schizophrenics distinguished from the neuro-psychiatric and normal controls by exhibiting a significant increase in the density of the low-affinity state, and a concomitant enhancement in the binding affinity of the high-affinity state of D1 dopamine receptors in caudate ...
A substantial and diverse body of literature suggests that the pathophysiology of schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an effective therapy for the management of positive psychotic symptoms, they are not
A fourth class of drugs, commonly known as “atypicals” but more properly calledatypicalantipsychotics orserotonin-dopamineantagonists, is related tochlorpromazineand to haloperidol. These antipsychotics can improve both the so-called positive symptoms (e.g.,hallucinations,delusions, and agitation) and ...
Dopamine D2-receptor density in humans as assessed with SPET and the new high-affinity ligand 123I-NCQ298: a pilot study. Dopamine D2SalicylamidesSchizophrenia脑放射性药物受体多巴胺D2Astra (S)-3-[123I]iodo-5,6-dimethoxyl-N-[(1-ethyl-2-pyrrolidinyl)methyl] -salicylamide (... E Ryding,...
TC15A BEHAVIOURAL AND DOPAMINE SENSITIZATION TO STRESS IN INDIVIDUALS AT RISK FOR PSYCHOSIS I. Myin-Germeys, M. Marcelis, P. Delespaul, J. van Os Page S32 select article TC15B PSYCHOSIS OUTSIDE OF THE RESEARCHER'S OFFICE: ASSOCIATION WITH “REAL TIME” STRESS AND PHYSIOLOGICAL AROUSAL Confe...
affinity states of D2, the antipsychotics are thought to specifically target these D2High states in psychosis in general and schizophrenia in particular.Keywords:: antipsychotic, brain imaging, domperidone, dopamine receptor, psychosis, schizophrenia, supersensitivity, 展开 关键词:antipsychotic brain...
Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis. Biol Psychiatry. 2010;68(7):599-60220638047PubMedGoogle ScholarCrossref 101. Staley JK, Krishnan-Sarin S, Zoghbi S, Tamagnan G, Fujita M, Seibyl JP, Maciejewski...
Clinical studies have confirmed that dopamine abnormalities are also present prior to the onset of psychosis in schizophrenia and thus are not a consequence of psychotic episodes or antipsychotic exposure. Similar to what has been observed in patients with schizophrenia, ultra-high risk (UHR) subjects...
Schizophrenia is noted for the remarkably high prevalence of substance use disorders (SUDs) including nicotine (>85%), alcohol and stimulants. Mounting evi... JT Coyle - 《Neurotoxicity Research》 被引量: 169发表: 2006年 Inhibition of stress-induced dopamine output in the rat prefrontal cortex ...
1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor, schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies over the last decade demonstrate that administration of low doses of NMDA receptor antagonists can cause in normal su...