Lack of association between two dopamine D2 receptor gene... S Caprini,P Saetre,I Melle,... - 《Psychiatric Genetics》 被引量: 0发表: 2011年 Association analysis between two functional dopamine D2 receptor gene polymorphisms and schizophrenia The dopamine D2 receptor (DRD2) gene has been ...
The dopamine system is a preferred object of biological research in schizophrenia. The evolving delidoi:10.1097/00041444-199322000-00004M. M. NöthenJ. KörnerL. LannfeltP. SokoloffB. F. O'DowdPsychiatric GeneticsN6thern MM, K6rner J, Lannfelt L, Sokoloff P, Schwartz JC, Lanczik ...
We then consider aetiological factors, highlighting how a range of similar genetic and environmental factors are associated with both cognitive function and schizophrenia. We then review the pathophysiological mechanisms thought to underlie cognitive symptoms, including the role of dopamine, cholinergic ...
Schizophrenia is a most disabling psychiatric disorder characterized by a myriad of symptoms. While the delusions and hallucinations are the most iconic symptoms of schizophrenia, patients also exhibit negative and cognitive symptoms. It is thought that
Schizophrenia, any of a group of severe mental disorders that have in common symptoms such as hallucinations, disordered thinking, and withdrawal from reality. Affected persons display a wide array of symptoms. The condition typically is treated with psy
(Box1), have been associated with reports of abnormalities in virtually every neurotransmitter system1,2,3,4,5. The onset of psychotic symptoms, which is strongly associated with alterations in dopamine function, is a key feature underpinning a clinical diagnosis6,7. However, results from ...
Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample. (2004). Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample. Arquivos de Neuro... Quirino,Cordeiro,Mi...
Abnormal Brain Chemicals. Schizophrenia is associated with an unusual imbalance of neurotransmitters (chemical messengers between nerve cells) and other brain chemicals, such as dopamine overactivity, glutamate, reelin, and others. Whether any changes in these chemicals in the brain is a cause or a ...
Many patients with schizophrenia respond relatively rapidly to low doses of dopamine antagonists and, thus, conform well to the predictions of the dopamine hypothesis. Other patients, however, respond only slowly and partially even to high doses. For such patients, alternate models are required. Th...
Schematic diagram summarizing the findings from our meta-analyses of dopamine function in schizophrenia. The diagram shows that the major dopaminergic abnormality in schizophrenia is presynaptic. The main findings from our meta-analyses are that presynaptic dopaminergic function is altered in schizophrenia,...