MILANESE C, SAGER J J, BAIS Q, et al. Hypokinesia and reduced dopamine levels in zebrafish lacking beta- and gamma1-synucleins[J]. J Biol Chem, 2012, 287(5):2971-2983. Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in F...
the dopamine hypothesis of schizophrenia was first proposed more than 30 years ago on the basis of indirect evidence. it received support from studies of postmortem brain tissue that found increased striatal d2/3 receptor density and dopamine levels in patients with schizophrenia and from studies of...
CONCLUSIONS: The locus of the largest dopaminergic abnormality in schizophrenia is presynaptic, which affects dopamine synthesis capacity, baseline synaptic dopamine levels, and dopamine release. Current drug treatments, which primarily act at D(2/3) receptors, fail to target these abnormalities. Future...
calledtardive dyskinesia. The atypical antipsychotics do not produce the movement disorders that are seen with the use of the older drugs, probably because of their affinity for both serotonin and dopamine receptors. None of the antipsychotics is curative, because none eliminates the fundamental disorde...
higher baseline synaptic dopamine levels in UHR subjects predicts a greater reduction in positive symptoms after dopamine depletion41. Overall, these findings in UHR subjects are congruent with those observed in schizophrenia and provide evidence indicating that presynaptic dopaminergic abnormalities are prese...
Cerebrospinal fluid levels of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)—5-hydroxyindoleacetic acid (5HIAA),... GL Brown,FK Goodwin,JC Ballenger,... - 《Psychiatry Research》 被引量: 2398发表: 1979年 An Inventory for Assessing Diferent Kinds ...
It received support from studies of postmortem brain tissue that found increased striatal D2/3 receptor density and dopamine levels in patients with schizophrenia and from studies of dopamine and its metabolites in cerebrospinal fluid.4-8 However, postmortem studies are not able to measure some ...
Schizophrenia is a most disabling psychiatric disorder characterized by a myriad of symptoms. While the delusions and hallucinations are the most iconic symptoms of schizophrenia, patients also exhibit negative and cognitive symptoms. It is thought that
Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels ...
A substantial and diverse body of literature suggests that the pathophysiology of schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an effective therapy for the management of positive psychotic symptoms, they are not efficacious for the complete schizophrenia symptom pro...