epidemiological systems characterized by(or) < 1. An epidemicity index can be defined and evaluated for any compartmental epidemiological model described as a set of ordinary differential equations, independently of the disease being addressed, the relevant route(s) of transmission, and the comple...
The emergence of highly divergent variants of SARS-CoV-2 has been a defining feature of the COVID-19 pandemic. Although the evolutionary origins of these variants are still a matter of speculation, multiple pieces of evidence point to chronic persistent infections as their most likely source5,7,...
In a passive immunization setting with IVIG/SCIG, this means not only trailing the epidemiology of donors in terms of neutralizing titer but also in terms of quality, meaning which variants will be neutralized best. 5 Conclusion Here, we report the onset of SARS-CoV-2 neutralizing antibodies ...
Plasma samples, statistical methods and meaning of labels are the same as in Fig. 2. All neutralization assays were conducted in at least two independent experiments. Article a BA.5 breakthrough infection (replicate) 100K 80K 100K 80K 100K 80K 60K 60K 60K 40K 20K 0 0 cells 88.7 20K ...
In summary, Omicron causes widespread escape from neutralization by serum obtained following infection by a range of SARS-CoV-2 variants, meaning that previously infected individuals will have little protection from infection with Omicron, although it is hoped that they will still maintain protection fr...
A positive antigen test result is considered very accurate, but there’s an increased chance of false negative results, meaning it’s possible to be infected with the virus but have negative antigen test results. So, antigen tests aren’t as sensitive as molecular tests. This type of test ...
At 0.5% prevalence applying the same tests in asymptomatic people would result in PPVs of 11% to 28% meaning that between 7 in 10 and 9 in 10 positive results will be false positives, and between 1 in 2 and 1 in 3 cases will be missed. No studies assessed the accuracy of repeated...
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of numerous variants that display growth advantages over BA.5 (ref. 1). Despite their divergent evolutionary courses, mutations on their receptor-binding domain (RBD) converge
(N) protein, and also several accessory proteins. The S, E, and M proteins together create the viral envelope, while the N protein holds the RNA genome. The name “coronavirus” is derived from the Latin word “corona” meaning crown or halo, and refers to the characteristic appearance of...
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure is related. For example, the Concise Dictionary of Biomedicine and Molecular Biology, Juo, Pei-Show, 2nd ed., 2002,...