The lack of consensus changes between many pairs of samples taken from the same infection, most of which are less than 2 months apart, is consistent with neutral evolution or weak selection, and indicates that there was limited within-host adaptation. In support of this, we identified 17 persi...
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes
Coronavirus (SARS-CoV-2), the cause of COVID-19, a fatal disease emerged from Wuhan, a large city in the Chinese province of Hubei in December 2019. The World Health Organization declared COVID-19 as a pandemic due to its spread to other countries inside
In a case report, a 45-year-old woman infected by SARS-CoV-2 initially received hydroxychloroquine (400 mg twice daily) and anticoagulant nadroparin (4 mg once daily); as her condition worsened, she was intubated. On the 9th day after the onset of symptoms, she was given human recombinant...
Data and Code Availability The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD019113 (Perez-Riverol et al., 2019). An interactive version of phosphorylation data can be found at https://kroganlab...
Other organ function support Organ function support is used to closely monitor the organ functions of children, including the nervous system, digestive system, urinary system, blood system, coagulation function, water-electrolyte acid-base balance, endocrine internal environment, and others, and then pr...
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The evaluation of antiviral lead compounds in WF-MLCE found the extract to be a rich source of polyphenolics, especially flavonoids and conjugates. To the best of our knowledge, this study demonstrates for the first time that the three flavonoid glycosides (myricetin 3-O-β-D-galactopyranoside,...
related cases were defined with various cutoffs for the maximum number of days between the case and the first observed case for each introduction lineage, as indicated by different colors.DThe origin of introductions across time for each region. If there was equal support for multiple regions as...
As used herein the term “exosome” is used interchangeably with “extracellular vesicle,” and refers to a cell-derived small (between 20-400 nm in diameter, more preferably 30-150 nm in diameter) vesicle comprising a membrane that encloses an internal space, and which is generated from the...