本发明涉及新型冠状病毒SARSCoV2NSP13基因的用途,将SARSCoV2NSP13蛋白制备成用于抑制乙肝病毒(HBV)复制的产品,或将SARSCoV2NSP13基因制备成允许表达SARSCoV2NSP13蛋白的产品,譬如重组质粒,重组蛋白和mRNA,通过不同方式向真核细胞中引入SARSCoV2NSP13蛋白都可以显著性地抑制HBV复制,具体表现在抑制HBV的转录和翻译.本...
Nsp3d负责蛋白寡聚体N端的切割,释放nsp1, nsp2和nsp3,因此也是一个潜在的药物靶点。RT复合物由多种酶组成,我们筛选了SCoV2推定的引物酶(nsp7和nsp8)和甲基转移酶(nsp14和nsp16)及其辅助因子nsp10复合物(nsp10⋅nsp14, nsp...
COVID-19, caused by the coronavirus SARS-CoV-2 (refs.1,2), continues to devastate the world. The viral RNA-dependent RNA polymerase (RdRp, encoded by nonstructural protein 12 or nsp12) functions as a holo-RdRp (comprising nsp7/nsp82/nsp12) in a replication–transcription complex (RTC) ...
The main virus-specific functions of the SARS-CoV-2 NSPs are: NSP1 - cellular mRNA degradation, global translation inhibition; NSP2 - cell cycle progression disruption; NSP3 - formation of double-membrane vesicles (DMVs; SARS-CoV-2 protease); NSP4 - formation of DMVs; NSP5 - main SARS-...
Nsps block the induction of type I interferon production. Nsp13 belongs to SF1 helicase superfamily and is a component of RTC [70]. Nsp13 of SARS-CoV2 shares a very high identity with SARS-CoV, which highlights its importance for viral replication [71]. It has been revealed that Nsp13 ...
例如,Edison等人(131)报告了使用反向疫苗学和机器学习预测SARS-CoV-2候选疫苗,包括S糖蛋白或非结构蛋白,如nsp3、3CL-pro和nsp8-10(131)。 SARS-CoV-2的新变种和S糖蛋白疫苗的有效性 SARS-CoV-2的新变种 新的SARS COV-2变种的...
As the global COVID-19 pandemic has led to intense researchers on SARS-CoV-2, a number of groups have independently determined cryo-EM structures of the core RTC complexed with the RNA substrate and two nsp13 helicases, with nsp9 regulating the cap synthesis in addition, and also the core...
1.本发明属于医药生物技术领域,具体的,涉及一种抗sars-cov2病毒感染导致的细胞因子风暴的药物。 背景技术: 2.在人类重大疾病死亡率中,癌症和重症感染性疾病晚期的死亡率占据着重要地位。其中一个主要死因是与细胞因子风暴相关的多种器官功能衰竭。细胞因子风暴是一种危及生命的全身炎症综合征,源于机体过度的免疫反应。
Nsp13 helicase is highly conserved in the coronaviruses family and pivotal in viral replication. Further studies are needed to investigate the effect of targeting CENPF and CIT as a possible therapeutic strategy to treat COVID-19. It is worth mentioning that the overexpression of CENPF and CIT,...
近日来自Duke-NUS医学院和A*STAR研究所等单位的研究人员在Antonio Bertoletti的带领下,首次研究了COVID-19恢复期病人(n=36)体内的T细胞对SARS-CoV-2的结构区(核衣壳蛋白,NP)和非结构区(ORF1的NSP-7和NSP13)的反应,相关研究成果发表在N...