冠状病毒是具有包膜的正链RNA病毒，SARS-CoV-2就是一种冠状病毒，其传播和扩散给世界健康和经济带来了巨大影响，冠状病毒的非结构性蛋白1（Nsp1）可以抑制宿主蛋白质合成，SARS-CoV-2的Nsp1 C端结构域可以结合核糖体的mRNA通道来抑制翻译，但是该机制在冠状病毒中是否广泛存在，Nsp1的N端结构域是否结合核糖体，以及...
Our results revealed that the SARS-CoV-2 non-structural protein 1 (Nsp1) plays a key role in viral immune evasion. It blocks the mRNA tunnel of the cellular ribosome, resulting in a shutdown of translation and strong attenuation of the host's antiviral immune response....
事实上,Nsp1是这种病毒用来确保自身在人类宿主中复制和传播的核心武器之一。近20年前,与SARS-CoV-2存在亲缘关系的SARS-CoV冠状病毒疫情爆发后,Nsp1就已被确认为一种致病因子,在当时它被发现能抑制受感染细胞的蛋白合成。 在一项新的研究中,来自德国慕尼黑大学和乌尔姆大学医学中心的研究人员确定了大流行性冠状病毒SAR...
The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, suppresses host innate immune functions. By combining cryo-electron microscopy and biochemistry, we show that SARS-CoV-2 Nsp1 binds to the human 40S subunit in ribosomal complexes, including the 43...
北京百普赛斯生物科技股份有限公司生产的NSP1蛋白,NSP1产品信息别称:NSP1物种:SARS-CoV-2属性:Protein标记:Unconjugated内毒素(Endotoxin)Lessthan1.0EU
(1). The NSPs are involved in the replication and transcription of the viral RNA and not incorporated within the virion particles. Coronaviruses include various highly pathogenic strains such as SARS-CoV, MERS-CoV and SARS-CoV2 that have had significant impact on humans as well as strains ...
pET28a-NSP1(SARS-CoV-2)基本信息 培养基酵母膏:5.0,蛋白胨:10.0,NaCl:10.0,pH:7.0(25℃) 生长条件LB +卡那霉素,37℃(克隆菌株DH5α) 存储条件2-8℃ 安全等级0 操作步骤1.溶解: 收到质粒干粉后,请加入 20μl 无菌水至管底,溶解质粒,室温静置 1min; 2.混合(吸附质粒): 200μl 感受态细胞 + 质粒...
近日,耶鲁大学熊勇教授团队在国际知名期刊Molecular Cell上发表了研究论文“Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA”,研究人员通过筛选新冠病毒蛋白和转...
近日,耶鲁大学熊勇教授团队在国际知名期刊Molecular Cell上发表了研究论文“Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA”,研究人员通过筛选新冠病毒蛋白和转录组分析发现Nsp1蛋白能够广泛改变细胞基因表达谱,利用结构生物学方法...
SARS-CoV-2 (COVID-19) NSP1 polyclonal antibody供应商 ProSci产品货号 PSI-11-044产品报价 ￥询价/0.1mg产品说明书 点击查看购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868产品新闻背景资料 SARS-CoV-2 (COVID-19) NSP1 polyclonal antibody应用...