The emergence of SARS-CoV-2 in late 2019 was followed by a period of relative evolutionary stasis lasting about 11 months. Since late 2020, however, SARS-CoV-2 evolution has been characterized by the emergence of sets of mutations, in the context of ‘variants of concern’, that impact ...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop a mild to moderate disease with virus replication restricted mainly to the upper airway
对存在 SARS-CoV-2 的未知样本的应对 我们如何更好地规划、鉴定我们在社区中发现的突变并做出响应? 病原体检测界正携手努力,针对新出现的 SARS-CoV-2 病毒突变开发解决方案。 显然,有必要继续开展鉴定这些样本的监测工作。最近出现了与对 SARS-CoV-2 样本进行测序以确认突变...
This review has highlighted the evolution of SARS-CoV-2 variants and the vaccine efficacy. Currently, various vaccine candidates are undergoing several phases of development. Their efficacy still needs to check for newly emerged variants. We have focused on the evolution, multiple mutants, waves of...
SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants John P. Moore, PhD; Paul A. Offit, MD JAMA Medical News & Perspectives Experts Discuss COVID-19—Vaccine Doses, Virus Variants, and More JAMA Viewpoint SARS-CoV-2 Variants of Concern in the United States ...
SARSCoV-2在过去 2 年中已在全球范围内传播,造成数亿例确诊感染和数百万人死亡。 SARSCoV-2 病毒刺突蛋白的受体结合域 (RBD) 启动与宿主受体血管紧张素转换酶 2 (ACE2)的结合,并作为病毒-细胞膜融合的初始重要步骤。针对 RBD 的中和抗体已显示出治疗和临床价。然而,已广泛观察到 SARS-CoV-2 变体对抗体和血...
SARS-CoV-2表面含有刺状糖蛋白,这是当前疫苗开发的主要目标,因为针对这种蛋白的抗体可以中和感染。公司和学术机构已开发出基于S糖蛋白及其抗原域和表位的疫苗,这些抗原域和表位已被证明能有效产生中和抗体。然而,新的SARS-CoV-2变种的出...
2 and TMPRSS2, the SARS-CoV-2 genome directly functions as an mRNA to translate two polyproteins from the ORF1a and ORF1b region, which are cleaved by two viral proteases into sixteen non-structural proteins (nsp1-16) to initiate viral genome replication and transcription. The SARS-CoV-...
Reportedly, missense and synonymous mutations were the most frequent type of mutations along the SARS-CoV-2 genome [27,35]. Of more than thousands of known variants with different frequencies, 17 high-frequency mutations have been reported in the literature, summarized in Table 1 and located on...
The new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2