新冠疫情一直在不断演变，引起了人们对SARS-CoV-2变种的关注。最近，《细胞》杂志发表了一篇关于这一话题的重要研究，研究人员探讨了SARS-CoV-2变种（Variants of Concern，VOC）如何影响我们的免疫系统以及对疫苗的挑战。SARS-CoV-2简介 SARS-CoV-2是导致COVID-19大流行的病毒。不同的病毒变种如Alpha、Delta、Beta...
Since the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants are categorized as the variant of interest (VOI), variant of concern (VOC), ...
新型冠状病毒SARS-CoV-2突变株总结: 目前为止总共6个变异株被美国CDC列为“Variants of Concern"(最新加入了Delta株),这些变异株在以下三个方面有比较严重的后果:1.病毒传播速度的改变;2. 对单克隆抗体治疗的敏感性;3. 能否被疫苗或自然感染产生的多克隆抗体有效中和。 Alpha突变株:B.1.1.7,最先在英国出现,在...
目前WHO将新冠病毒的变异株分为高关注变异株(variants of concern,VOCs)、需留意变异株(variants of interest,VOIs)和需监测变异株(variants of interest,VUMs),其中Alpha (B.1.1.7)、 Beta (B.1.351), Gamma (P.1)和Delta (B.1.617.2)都归为VOCs,这些变异毒株在世界上的不同地区掀起了不同程度的人群传...
(mRNA1273, BNT162b2) to prevent SARS-CoV-2 infections (https://extranet.who.int/pqweb/vaccines/covid-19-vaccines). However, circulating variants including Delta have posed enormous challenges to the effectiveness of vaccines. Delta, also termed B.1.617.2 variant, detected in India in ...
2022年1月27日,中国医学科学院深圳传染性疾病防控研究中心、深圳市疾病预防控制中心、中国医学科学院病原生物学研究所和中科院北京基因组研究所(国家生物信息中心)的研究人员任丽丽、李明锟等人在Emerging Microbes & Infections在线了一篇题为Possible recombination between two variants of concern in a COVID-19 patient...
A large study from Ontario confirms that SARS-CoV-2 variants of concern (VOCs), especially the Delta variant, are more virulent than the native strain of the virus, increasing people's risk of hospitalization, admission to the intensive care unit (ICU) and death due to COVID-19. The resea...
2022-06-23报道,在一项新的研究中,来自德国乌尔姆大学的研究人员发现SARS-CoV-2依赖于具有广泛抗病毒作用的干扰素诱导人类跨膜蛋白(interferon-induced human transmembrane protein, IFITM),以进入人类细胞并在其中复制。相关研究结果近期发表在Journal of Virology期刊上,论文标题为“SARS-CoV-2 Variants of Concern Hij...
most current variants of concern (Beta, Gamma, Omicron). Position 501 in the S protein is within the receptor-binding motif (RBM) and is one of the six contact amino acid (a.a.) residues with ACE2. N501Y has been shown to improve the binding affinity of SARS-CoV-2 to ACE2 [9, ...
Coronavirus disease 2019 (COVID-19) has become a global pandemic disease. SARS-CoV-2 variants have aroused great concern and are expected to continue spreading. Although many countries have promoted roll-out vaccination, the immune barrier has not yet been fully established, indicating that populati...